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EC number: 253-391-7 | CAS number: 37203-76-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-01-08 - 2001-03-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Ethyl dihydrogen phosphate
- EC Number:
- 216-603-9
- EC Name:
- Ethyl dihydrogen phosphate
- Cas Number:
- 1623-14-9
- Molecular formula:
- C2H7O4P
- IUPAC Name:
- Phosphoric acid,monoethyl ester
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Phosphoric acid mono-/di-ethylesterChemical name:
Molecular formula: x C2H7O4P * y C4H11O4P
CAS-Number: 1623-14-9,598-02-7
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test substance was weighed into a beaker, mixed with water for dilution and homogenized with the Ultra-Turrax to ensure that the solubility limit of the test substance in the test water is reached.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species
Daphnia magna - Clone 5 {IRChA, France)
Origin
Stock culture of Aventis Pharma Deutschland GmbH, ProTox
Breeding conditions
100 mL beakers (height 90 mm, diameter 50 mm), filled with 70 mL test water (according to Elendt, M4) served as culture vessels. One daphnid was used per culture vessel. The animals were used for breeding up to an age of 42 days. The reproduction rate and the state of health of the animals were monitored daily apart from weekends. The animals were fed three times a week with monocellular green algae {Scenedesmus subspicatus).
The supplied diet was based on the amount of organic carbon (C), The ration level is 0.2 mg carbon / day / animal.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- The total hardness of the dilution water was 2.1 mmol Ca2+ + Mg2+ / L during the study.
- Test temperature:
- 20.3-21.1 °C
- pH:
- 6.1-6,3
- Dissolved oxygen:
- 8.5-8.8 mg/l
- Nominal and measured concentrations:
- 100 mg/l nominal
103 mg/l measured - Details on test conditions:
- After the test concentrations had been prepared and water parameters were recorded, 10 daphnids were used in each test chamber. The daphnids were not fed during the entire study period. Inspection of the daphnids took place after 24 and 48 hours and involved recording the immobility. Immobile daphnids were removed from the chambers. Those animals which were not able to swim within 15 seconds after gentle agitation of the test container were considered to be immobile. The water parameters were measured after adding the substance and at the end of the test.
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In this 48-hour acute toxicity study of Hordaphos MDE rn Daphnia magna (water flea) no immobility occurred in the 100 mg/L-group (nominal concentration) and in the control group.
Under the conditions of this test the EC50 of Hordaphos MDE after 48 hours was 100 mg/L. - Executive summary:
Hordaphos MDE was tested in Daphnia magna (water flea) for 48 hours in a static system. The concentration tested was 100 mg/L and a control (0 mg/L). The tested concentration was present as a clear solution. All test batches were homogeneous. No particulate matter was observed. The substance concentration was determined in the 100 mg/L group. The values determined were in a range of + 10 % of the theoretical value.
In this 48-hour acute toxicity study of Hordaphos MDE the following immobility values were determined:
after 24 hours
after 48 hours
ECo (mg/L)
> 100
> 100
EC5o (mg/L)
> 100
> 100
EC-1oo (mg/L)
> 100
> 100
The 100 mg/L group showed no effect in comparison to the negative control.
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