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EC number: 233-986-8 | CAS number: 10482-56-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 July 2018 - 27 July 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Test method according to EEC method A.6. and OECD Guideline 105. GLP study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 2.23 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- >= 6.44 - <= 6.76
- Details on results:
- Solubility of the test item at 20 ± 0.5ºC and at pH ranging 6.44–6.76 in water is 2.23 g/L.
- Conclusions:
- Solubility of laevo alpha terpineol at 20 ± 0.5ºC and at pH ranging 6.44–6.76 in water is 2.23 g/L.
- Executive summary:
The water solubility test of laevo alpha terpineol was performed in accordance with EEC method A.6 and OECD 105. About five times the quantity of test item determined in the preliminary test was weighed into each of three glass vessels at 100 ml fitted with glass stoppers. 70 ml of double distilled water was added to each vessel. These closed vessels were agitated in an incubator at 30 ºC with magnetic stirrers. After one day, one of the flask was equilibrated for 24 h at the test temperature 20 ± 0.5 ºC with occasional shaking. The other two flasks were treated similarly after initial equilibration at 30 ºC for two and three days respectively. Two replicates were performed. The samples taken during saturation were then separated using a vial-centrifuge to give the clear liquid phase and the concentration of the test substance in the clear solvent phase was determined by a validated GC method. The solubility of laevo alpha terpineol in distilled water at pH 6.44 -6.76 was determined to be 2.23 g/l at 20 ± 0.5 °C.
Reference
Table 1. Results of the preliminary test
0.1g in x mL of solution |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
> 100 |
Soluble (+/-) |
- |
- |
- |
- |
- |
+ |
|
Approximate solubility, g/L |
> 1000 |
1000 to 200 |
200 to 100 |
100 to 50 |
50 to 10 |
10 to 1 |
<1 |
Table 2. Study solution in water
Sample day/ flask |
Weight of the sample [mg] |
Dilution [mL] |
Cp [mg/mL] |
Peak area |
Average peak area Ap |
X [g/kg] |
||
1 |
1 |
1011.34 |
10 |
101.13 |
3821.89 |
3835.98 |
3828.94 |
2.4155 |
2 |
1013.63 |
101.36 |
3855.7 |
3869.26 |
3862.48 |
2.4312 |
||
2 |
3 |
1012.20 |
10 |
101.22 |
3368.55 |
3373.7 |
3371.13 |
2.1291 |
4 |
1009.10 |
100.91 |
3294.0 |
3277.2 |
3285.59 |
2.0815 |
||
3 |
5 |
1010.50 |
10 |
101.05 |
3369.21 |
3374.38 |
3371.80 |
2.1357 |
6 |
1006.10 |
100.61 |
3448.49 |
3441.57 |
3445.03 |
2.1917 |
Table 3. Results of Laevo alpha terpineol solubility in water
Mixing time at 30 ºC [days, flasks] |
1 |
2 |
3 |
|||
Samples |
1 |
2 |
3 |
4 |
5 |
6 |
Temperature, ºC |
19.9 |
20.2 |
20.0 |
|||
pH |
6.44 |
6.69 |
6.76 |
|||
Concentration of Laevo alpha terpineol, g/kg |
2.4155 |
2.4312 |
2.1291 |
2.0815 |
2.1357 |
2.1917 |
Average concentration of Laevo alpha terpineol, g/kg |
2.4234 |
2.1053 |
2.1637 |
|||
Average concentration Laevo alpha terpineol, g/kg |
2.2308 |
The solubility of Laevo alpha terpineol in water is 2.23 g/kg. The density of this solution is about 1 kg/L (about water density). After recalculation:
The solubility of Laevo alpha terpineol at pH 6.44 – 6.76 in water is 2.23 g/l.
Description of key information
Key study: Test method EEC A.6 and OECD 105. GLP study. The solubility of laevo alpha terpineol in distilled water at pH 6.44 -6.76 was determined to be 2.23 g/l at 20 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 2.23 g/L
- at the temperature of:
- 20 °C
Additional information
Key study: The water solubility test of laevo alpha terpineol was performed in accordance with EEC method A.6 and OECD 105. A preliminary test was performed to determine an approximately solubility of test item. For the main test, three experiments (100 mL glass vessels with specified quantity of test item in distilled water) with different equilibration times of 24, 48 and 72 h each at 20ºC were conducted. Two replicates were performed. The concentration of the test substance in the aqueous phase was determined by a validated GC method. The solubility of laevo alpha terpineol in distilled water at pH 6.44 -6.76 was determined to be 2.23 g/l at 20 ± 0.5 °C.
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