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EC number: 412-180-1 | CAS number: 10221-57-5 1,2-DIETHOXYPROPANE; DIETHOXY-1,2-PROPANE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17th August 1991 - 2nd Decmber 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-diethoxypropane
- EC Number:
- 412-180-1
- EC Name:
- 1,2-diethoxypropane
- Cas Number:
- 10221-57-5
- Molecular formula:
- C7H16O2
- IUPAC Name:
- 1,2-diethoxypropane
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch No.of test material: 9059
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: The test material, a colourless liquid, was stored in the dark under ambient conditions.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Limited, Abbots Ripton Road, Wyton, Huntingdon
- Age at study initiation: young adult
- Housing: The rabbits were housed individually in aluminium cages with grid floors beneath which were peat moss filled trays.
- Diet: Standard Rabbit Diet, supplied by Special Diets
Services, 1 Stepfield, Witham, Essex, CM8 3AD ad libitum
- Water: tap water ad libitum
- Acclimation period: 13 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-20 °C
- Humidity (%): 57%
- Photoperiod (hrs dark / hrs light): A 12 h light/dark cycle was in operation
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Ethylene glycol diethyl ether (ethyl glyme),
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 mL
- Concentration (if solution):undiluted
0.5mL of the control material, ethylene glycol diethyl ether (ethyl glyme) was also applied. - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 1, 24, 48 and 72 h after patch removal. Further assessments were carried out at 5, 6, 8, 9, 10 and 11 days after patch removal to determine the reversibility of responses.
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: The hair was clipped from the dorsal area of the trunk of each rabbit approximately 24 h before treatment. Care was taken to avoid abrading the skin.
- % coverage: The test and control materials (0.5 ml) were applied to intact skin on each rabbit under 2.5 cm x 2.5 cm patches of gauze.
- Type of wrap if used: Due to the volatility of the test material, the patches were covered with Sleek, an occlusive dressing, which remained in position for 4 h.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The patches were removed and the skin wiped with water dampened tissues to remove surplus test material without altering the existing response or the integrity of the epidermis.
- Time after start of exposure: After 4 hr exposure period
OBSERVATION TIME POINTS
(indicate if minutes, hours or days)
1, 24, 48 and 72 h after patch removal. Further assessments were carried out at 5, 6, 8, 9, 10 and 11 days after patch removal to determine the reversibility of responses.
SCORING SYSTEM:
- Method of calculation: The daily scores for erythema and oedema for the test and control material at the 24, 48 and 72 h assessments were totalled and the mean was calculated. This mean value is expressed as a mean irritation score for each material. The Draize scoring system was used (Appendix).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: animals 1 & 2
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- other: animals 1 & 2
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- other: animals 1 & 2
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 11 days
- Remarks:
- Erythema = 1
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 11 days/Erythema = 1
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- overall irritation score
- Remarks:
- erythema
- Basis:
- animal: 1,2,3
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 11 days
- Remarks:
- Animal #3 erythema = 1
- Irritation parameter:
- overall irritation score
- Remarks:
- oedema
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- overall irritation score
- Remarks:
- oedema
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- overall irritation score
- Remarks:
- oedema
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- Following a 4 h application of both the test and control materials, very slight to well defined erythema and very slight to slight oedema were noted up to 72 h after patch removal. At 5 days skin reactions deteriorated at a test site treated with test material and a test site treated with control material on one rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo skin irritation study in male New Zealand rabbits, the substance 1,2-Diethoxypropane was not irritating.
- Executive summary:
In a primary dermal irritation study (8280), 3 male rabbits were dermally exposed (dorsal area of the trunk; occlusive) to 0.5mL of undiluted 1,2-Diethoxypropane for 4 hours. The substance was removed after 4 hrs with washing. Animals were observed at 24, 48 and 72 hrs for overall irritation scores and up to 11 days for reversibility. Irritation was scored by the method of Draize.
The overall irritation score (erythema) for all animals was 1.33. In only 1 animal (#3) the irritation was not fully reversible at Day 11 (erythema = 1). The overall irritation score (oedema) for animal #1 was 0. The overall irritation score (oedema) for animal #2 was 1.33 (fully reversible within 10 days). The overall irritation score (oedema) for animal #3 was 0.66 (fully reversible within 8 days). The observations were not extended to 14 days. In only 1 animal (#3) was the erythema not fully reversible at Day 11 (erythema = 1). Overall, based on the CLP criteria, the substance is not irritating.
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