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EC number: 237-377-8 | CAS number: 13767-32-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 July 2018 - 08 August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Molybdenum zinc tetraoxide
- EC Number:
- 237-377-8
- EC Name:
- Molybdenum zinc tetraoxide
- Cas Number:
- 13767-32-3
- Molecular formula:
- MoO4Zn
- IUPAC Name:
- molybdenum(6+) zinc(2+) tetraoxidandiide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Slovak Academy of Sciences Dobrá Voda, Slovak Republic
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 89-203g
- Fasting period before study: Animals were fasted 10-12 h prior to dosing (food but not water was withheld over-night).
- Housing: 3 animals per cage, in plastic cages suspended on stainless steel racks.
- Diet (e.g. ad libitum): Ad libitum (ssniff Spezialdiäten GmbH, Germany)
- Water (e.g. ad libitum): Ad libitum (tap water)
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.96 ± 0.46 °C
- Humidity (%): 54.83 ± 2.65 %
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12-hour light /12-hour dark cycle.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 5 mL/kg bw
- Justification for choice of vehicle: Common vehicle according to the OECD TG 423. It was chosed based on preliminary works.
- Lot/batch no. (if required): L71143
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw
DOSAGE PREPARATION (if unusual): The required amount of the test item (according to the body weight and dose) was mixed with vehicle (Olive oil) shortly before administration.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: A limit dose of 2000 mg/kg bw was used as a starting dose (no adverse effects expected). - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females (in two steps, 3 rats per step).
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical signs: Immediately after administration and 0.5, 1, 2, and 4 hours later. Daily for the next 14 days.
Parameters: changes in skin, fur, eyes, mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity, and behavioural pattern. Particular attention was given to potential neurologic endpoints such as tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
Body weight: Immediately prior to administration and weekly thereafter.
- Necropsy of survivors performed: yes
Parameters: External appearance, the cranial, thoracic and abdominal cavities, the appearance of the tissues and organs.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 5/6 females survived the limit dose of 2000 mg/kg body weight. Test item-related mortality was observed in one animal on the 3rd day after administration without any previous clinical symptoms.
- Clinical signs:
- other: During the study, no animals displayed signs of intoxication, change of health, nor any other adverse reaction.
- Gross pathology:
- No macroscopic findings were observed.
Dead animal could not be necropsied because of autolysed cadaver.
Any other information on results incl. tables
Body weight:
Sex |
Dose |
ID |
Body Weight (g) |
Body Weight Difference (g) |
||||
Initial |
Week 1 |
Week 2 |
Week 1 - Initial |
Week 2 - Initial |
Week 2 - Week 1 |
|||
♀ |
2000 mg/kg |
1 |
197 |
184 |
215 |
-13 |
18 |
31 |
2 |
189 |
195 |
215 |
6 |
26 |
20 |
||
3 |
192 |
189 |
202 |
-3 |
10 |
13 |
||
4 |
203 |
184 |
209 |
-19 |
6 |
25 |
||
5 |
194 |
- |
- |
- |
- |
- |
||
6 |
203 |
170 |
203 |
-33 |
0 |
33 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 of the test item is greater than 2000 mg/kg body weight after single oral administration to Wistar rats. The LD50 cut off value was determined to be 2500 mg/kg body weight.
- Executive summary:
An acute oral toxicity test was performed according to the OECD Guideline 423 (GLP study). The test item was administered in a single dose of 2000 mg/kg bw by gavage. One group of 3 females was dosed. Test item-related mortality was not observed during 24 hours and therefore, in a second step, another 3 females were treated at the same dose. Animals were observed for 14 days. Individual weights of animals were measured. All test animals were subjected to gross necropsy. The test item caused death of one animal. No signs of toxicity were observed during the first 4 hours or the 14-day observation period thereafter. The body weights of all survived animals decreased during the first week after administration of the test item except one animal. No body weight losses were observed between the first and second week after administration. During necropsy, no macroscopic findings were observed. The LD50 of the test item is greater than 2000 mg/kg body weight after single oral administration to Wistar rats. The LD50 cut off value was determined to be 2500 mg/kg body weight.
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