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EC number: 202-443-7 | CAS number: 95-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14.05.2018 - 22.06.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- accredited by DAkkS
- Analytical monitoring:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Caging of the fish was conducted in 40 l-glas pools under permananent ventilation at 20 +/- 5°C and a 12 h/12 h light-dark rhythm. The animals were fed daily.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 4 d
- Test temperature:
- see table 2
- pH:
- see table 2
- Dissolved oxygen:
- see table 2
- Nominal and measured concentrations:
- for nominal concentrations see table 2
- Details on test conditions:
- As pre-treatment the test organisms were transferred in a 15 l- glas pool 7 days before the start of the test. This pool contained a solution (see table 1 for the composition) where the test organisms were kept under equal conditions. Within this week, the mortality of the of the fishes was observed. Since no fish died in this week, the main test was carried out. Feeding of the fish was suspended 24 h before test start.
Before the start of the test, 6 10 l-glas pools were filled with 5 l of the solution (see table 1 for the composition) and ventilated for approx. 1 h in each case. Subsequently, the water was left for 12 h. Then, samples of methylhydroquinone in different concentrations (pools B - F) were added. Pool A was not exposed to the test item and was used as control sample. Next, 7 fishes from the pre-treatment pool were each placed in the sample solutions and kept at 20 +/- 2°C for 96 h without ventilation in a 12 h-12h light-dark rhythm. The measurement and documentation of oxygen content, pH-value, temperature and number of the fishes was conducted at 24 h intervals. Dead fishes were removed immediately.
The concentration range was determined in pre-tests by fish egg test according to OECD guideline. - Reference substance (positive control):
- no
- Key result
- Duration:
- 4 d
- Dose descriptor:
- LC50
- Effect conc.:
- 1.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The value for the LC50 was calculated from the equation of the regression curve using measured values of the concentrations 0,9 mg/l and 1,6 mg/l.
- Sublethal observations / clinical signs:
Table 2: Oxygen content, pH-value, temperature and number of the fishes in the control sample and test samples in the test period of 96 h
Test period [h]
parameter
concentration in mg/l
0
0,5
0,9
1,6
2,9
5,2
0
oxygen content [mg/l]
8,87
8,87
8,86
8,84
8,82
8,92
pH
7,51
7,45
7,53
7,52
7,51
7,52
temperature [°C]
21,0
20,9
20,8
21,0
20,3
20,3
number of living fishes
7
7
7
7
7
7
24
oxygen content [mg/l]
6,56
7,30
7,43
8,01
7,47
6,21
pH
7,06
7,23
7,08
7,25
7,30
7,30
temperature [°C]
21,2
18,8
18,9
19,0
21,1
20,6
number of living fishes
7
7
7
0
0
0
48
oxygen content [mg/l]
6,08
6,01
6,10
/
/
/
pH
7,07
7,09
7,16
/
/
/
temperature [°C]
21,5
19,2
19,5
/
/
/
number of living fishes
7
7
7
0
0
0
72
oxygen content [mg/l]
6,02
6,71
6,99
/
/
/
pH
7,02
7,06
7,09
/
/
/
temperature [°C]
21,5
19,8
19,7
/
/
/
number of living fishes
7
7
7
0
0
0
96
oxygen content [mg/l]
6,24
4,42
4,66
/
/
/
pH
7,10
6,92
7,01
/
/
/
temperature [°C]
21,4
19,3
19,1
/
/
/
number of living fishes
7
7
7
0
0
0
mortality [%]
100
100
100
0
0
0
- Validity criteria fulfilled:
- yes
- Remarks:
- The validity of the test is given since all fishes have survived in the control samples and the oxygen content did not decrease 60% of the air saturation.
- Conclusions:
- The acute toxicity of methylhydroquinone to Danio rerio was investigated in a study according to OECD Test No. 203: Fish, Acute Toxicity Test. The 96 h LC50 was determined to be 1.20 mg/L.
- Executive summary:
This study is based on OECD Guideline 203. 7 fishes (species: danio rerio) were exposed at 0 (control), 0.5, 0.9, 1.6, 2.9 and 5.2 mg/L (nominal), for 96 hours with measurement of mortality.
The 96-hour LC50 for the test substance methylhydroquinone to danio rerio is 1.20 mg/L.
Reference
Description of key information
Based on a OECD 203-study, the 96-hour LC50 for the test substance methylhydroquinone to danio rerio is 1.20 mg/L as determined in a static freshwater test.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.2 mg/L
Additional information
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