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Diss Factsheets
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EC number: 203-744-6 | CAS number: 110-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term fish toxicity to fish
The short-term toxicity of TMEDA to fish was determined in a 96-hour static test performed according to USEPA TSCA 40 CFR Part 797.1400 Guideline and in compliance with GLP (Tepper, 1988). The 96 -h LC50 was 240 mg/L. The lowest concentration causing 100% mortality was 320 mg/L and the highest concentration causing no mortality was 180 mg/L. All concentrations are reported as nominal concentrations.
Short-term fish toxicity to aquatic invertebrates
The short-term toxicity of TMEDA to Daphnia magna was determined under semi-static conditions in an OECD 202 Guideline study and in compliance with GLP (Kümich, 2018). The 48-h EC50 was >76 mg/L (actual, geomean measured) and the corresponding 48-h NOEC was 38.5 mg/L (actual).
Toxicity to aquatic algae and cyanobacteria
The effects of TMEDA on the growth of the unicellular freshwater alga Pseudokirchneriella subcapitata were determined in a 72-hour static test performed according to OECD 201 and in compliance with GLP (Schuster, 2018). The 72 -h ErC50 causing a 50% reduction in specific growth rate compared to the untreated control was 20.5 mg/L (95% CL: 11.7 to 37.9 mg/L). The ErC10 was 4.82 mg/L and the corresponding NOErC was 0.954 mg/L.
Toxicity to microorganisms
The toxicity control treatment of the available OECD 301B ready biodegradability test for TMEDA (Flach, 2018) demonstrated that there was no toxicity to activated sludge microorganisms following exposure of 40 mg/L organic carbon (corresponding to 56.7 mg TMEDA/L). As such, a NOEC of 56.7 mg/L is concluded for microorganisms.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.