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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Effect of the inhalation of a surface tension-reducing substance (propylene glycol) ono the ultrastructure of the epithelium of the respiraatoy passages in rabbits
Author:
Konradova V., Vavrova V., Janota J.
Year:
1978
Bibliographic source:
Folia Morphologica 26, 28-34

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Six rabbits were exposed for either 20 or 120 minutes to an aerosol of monopropylene glycol (10% in air). In each experimental group the tracheal epithelium of 3 rabbits was examined.
GLP compliance:
no
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propane-1,2-diol
EC Number:
200-338-0
EC Name:
Propane-1,2-diol
Cas Number:
57-55-6
Molecular formula:
C3H8O2
IUPAC Name:
propylene glycol
Details on test material:
Source: Dow Chemical company, Freeport, Texas
Purity: 99%
Appearance: clear liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Weight at study initiation: 2000-3000 mg

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:TRI-airborne infection apparatus
- Source and rate of air: 10 l air/minute
- System of generating particulates/aerosols: glass inhalator by Synek
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 20 - <= 120 min
Remarks on duration:
Exposure duraction was either 20 min or 2 hours
Concentrations:
10% monopropylene glycol in air (100000 ppm, 317041 mg/m3)
No. of animals per sex per dose:
3 per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 317 042 mg/m³ air
Exp. duration:
2 h
Other findings:
20 minutes inhalation of 10% propylene glycol produced minimal alteration of ciliated cells, but it represented a strong secretory impuls for the goblet ones. After shorter inhalation 16.5% of goblet cells filled with large pale mucous granules, 31% of mucus discharging and 52% of completely exhausted ones with highly electron dense degenerated cytoplasm were observed. After 2 hours inhalation of monopropylene glycol signs of ciliated cells' alteration were more pronounced and a slight drop in the number of intact mucus filled (12%) and mucus discharging goblet cells (19%) was accompanied by an increase in the number of exhausted degenerated ones (69%). The degenerated goblet cells were gradually expelled from the epithelium. Even after 2 hours' inhalation the signs of increased differentiation of new goblet cells were not noticed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

The test substance has an inhalation LD50 > 317 042 mg/m³ air.