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EC number: 814-433-5 | CAS number: 926622-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Assessment of the toxicokinetic behaviour
Since no toxicokinetic studies are available for 2-Propanamine, N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-2-methyl-, the following assessment is based on the available physicochemical properties and results from other toxicological studies:
2-Propanamine, N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-2-methyl- is a transparent, clear and homogeneous liquid with a molecular weight of 219.3244 g/mol, indicative for a favourable absorbance of the test item.
The test item is miscible with water at 20.0°C in any ratio. Due to this high water solubility, it is predicted that the test item is readily dissolved into the gastrointestinal fluids.
Due to the relatively low vapour pressure of the test substance (0.0082 hPa at 20°C), the volatility of the substance is rather very low and inhalation exposure to vapors is hence considered to be also low.
Adsorption
The partition coefficient of the test substance (log Pow) is 0.9 at 23°C at pH 11.0. Based on this rather low partition coefficient the test substance is unlikely to bioaccumulate with the repeated intermittent exposure patterns normally encountered. However, this low log Pow value and the high water solubility and the small molecular weight indicates that the substance might be favourable for passive diffusion. In line with this, in an acute oral toxicity study, two out of three females died after administration of 2000 mg/kg bw, whereas animals receiving 300 mg/kg bw did not show any signs of mortality (LD50> 300 - < 2000 mg/kg bw). Furthermore, animals receiving the high dose showed clinical signs and symptoms of intoxication: poor and impaired general state, dyspnea, cowering positions, piloerection and reduced defecation. These observations are in line with the low log Pow value, showing that the substance is systemically bioavailable when administered orally. It is therefore assumed that the test substance or its possible metabolites become systemically available after absorption along the gastro-intestinal tract.
Furthermore, the substance is corrosive (BASF, 2018) further supporting the notion that there is a high bioavailability of the substance via the dermal route.
Distribution
Since 2-Propanamine, N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-2-methyl- is a small water-soluble molecule it probably diffuses through aqueous channels and pores. Therefore, a distribution into different organs is assumed.
Metabolism
Using the OECD toolbox vs.4.2, the in vivo Rat metabolism simulator provided 13 potential simulated metabolites, as well as 5 simulated skin metabolites. Studies assessing genotoxicity (Ames-Test; BASF, 2018) was negative, i.e. there is no indication of a reactivity of the test substance or its metabolites with macromolecules under the chosen test conditions.
No further data available.
Excretion
No data available.
Based on the molecular weight of the parent compound and its water solubility, it is conjectured that the test substance would probably primarily undergo a renal elimination.
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