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EC number: 221-359-1 | CAS number: 3077-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the available read-across data, it is concluded that the target substance does not cause growth inhiibtion to aquatic algae. The retained key values for the toxicity of the target substance to aquatic algae are a NOEC (72 h) of 100 mg/L and an ErC50 (72 h) of greater than 100 mg/L based on growth rate.
- Executive summary:
The toxicity of the source substance Accelerator (PT 25E or PT 25E/2) was assessed according to OECD guideline 201. Pseudokirchneriella subcapitata were exposed to the nominal concentrations of 0 (blank-control), 0.1, 1, 10 and 100 mg/L for 72 h.
Both the EC50 for growth rate reduction (72h-ErC50) and the EC50 for yield inhibition (72h-EyC50) exceeded the analytically confirmed concentration of 100 mg/L. The 72h-NOEC for growth rate reduction was 100 mg/L. For yield, the 72h-NOEC was between analytically confirmed concentrations of 10 and 100 mg/L. The study is considered to be reliable without restrictions.
The target substance is expected to have a similar ecotoxicological profile as the source substance based on the high degree of structural and chemical similarity between the source and the target substances. Therefore, it is concluded that the key value for the toxicity of the target substance to aquatic algae is a NOEC (72 h) of ≥ 100 mg/L and an ErC50 (72 h) of > 100 mg/L.
Reference
Description of key information
ErC50 (72 h) > 100 mg/L (nominal, OECD 201, P. subcapitata); read-across
NOEC (72 h) ≥ 100 mg/L (nominal, OECD 201, P. subcapitata); read-across
Key value for chemical safety assessment
Additional information
There is no study available, in which the toxicity of the target substance N,N-Dihydroxyethyl-p-toluidine (CAS 3077-12-1) to aquatic algae was assessed. Therefore, read-across to the structurally and chemically closely related source substance Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- (EC 911-490-9) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 in order to meet the standard information requirements laid down in Annex VIII of REACh Regulation (EC) No 1907/2006. Based on the high degree of physico-chemical similarity between the target and source substances, the selected source substance is considered a suitable representative for the assessment of the toxicity of the target substance to aquatic algae. A detailed read-across approach justification is provided in IUCLID section 13.
In the available study with the source substance, the freshwater alga (Pseudokirchneriella subcapitata) was exposed to the nominal concentrations of 0.1, 1, 10 and 100 mg/L, including a negative control for 72 h. The test item concentrations in the test vessels were analytically verified and it was shown that the substance concentration was stable throughout the exposure.
After 72 h, no effects on growth rate were recorded, resulting in a NOEC (72 h) of ≥ 100 mg/L and an ErC50 (72 h) of > 100 mg/L
Based on the high degree of structural and chemical similarity between the target and the source substance and since the target substance is the main constituent of the source substance, the target substance is expected to exhibit a similar ecotoxicological profile as the selected source substance. Therefore, it is concluded that the target substance N,N-Dihydroxyethyl-p-toluidine (CAS 3077-12-1) does not cause toxic effects to aquatic algae up to a nominal concentration of 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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