Registration Dossier
Registration Dossier
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EC number: 255-615-9 | CAS number: 41999-70-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The test substance (CAS No 41999-70-6, EC No 255-615-9) is a colorless liquid with a high water solubility (miscible), a low log Kow (-1.23) and a moderate vapour pressure (2 Pa at 25°C). It has a molecular weight of 132.2 g/mole. The substance is found to be classified as acute oral and acute dermal toxicant (category 4), skin corrosive (category 1B) and as skin sensitizer category 1B.
No toxicokinetic data (animal or human studies) are available on this substance. The data present in this dossier are based on physico-chemical parameters and will allow a qualitative assessment of the toxicokinetic behaviour of the test substance.
The following absorption factors were established based on the available data: oral 50%, dermal 50% and inhalation 100%.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Absorption
Oral/GI absorption
Following its high water solubility (100 g/L as limit value), the test substance will readily dissolve into the gastrointestinal fluids and subsequently pass through aqueous pores or be carried through the epithelial barrier by the bulk passage of water. Based on its relatively low molecular weight (132.2 g/mole) and the low log Kow (-1.23), absorption by passive diffusion will be favoured. In general, after oral administration, absorption takes place in the intestine. Data on intestine pH for different species are rare and most stem from relatively old sources (ECHA guidance on IR&CSA, R.7c). Assuming a median intestinal pH value close to 7, the pKa of the test substance suggests that this substance will be predominantly in its ionized form. It is generally thought that ionized substances do not readily diffuse across biological membranes. Therefore, it could be concluded that the diffusion across biological membranes of the test substance will be hampered.
The test substance has been tested in a subacute oral toxicity study (Combined repeated oral toxicity study with the reproduction/developmental toxicity screening test; OECD 422); a NOAEL of 450 mg/kg bw/d was derived.
The oral absorption factor is set to 50%, based on the anticipated hampered diffusion of the test substance as an ionized substance. The results of the toxicity studies do not provide reasons to deviate from this proposed value.
Respiratory absorption
Given the vapour pressure of 2 Pa, the test substance is not a highly volatile substance and the availability for inhalation as a vapour is limited.
Once in the respiratory tract, the hydrophilic substance may be retained within the mucus, and subsequently absorption may occur. Absorption directly across the respiratory tract epithelium by passive diffusion is favoured in view of the low log Kow value. Based on the above considerations,the inhalatory absorption factor is set to 100%.
Dermal absorption
In view of its high water solubility and moderate log Kow, penetration into the lipid-rich stratum corneum and hence dermal absorption might be limited although its physical form (liquid) and relatively low molecular weight (132.2 g/mole) favours dermal absorption.
The test substance is demonstrated to be skin corrosive category 1B and skin sensitizing category 1B. Adverse effects were observed in an acute dermal toxicity study performed according to OECD guideline 402. The dermal LD50 of the test substance was estimated to be greater than 1000 mg/kg but less than 2000 mg/kg. The substance is classified as acute dermal Cat 4 under CLP.
The dermal absorption factor for the test substance is set to 50%. The results of the toxicity studies do not provide reasons to deviate from this proposed value.
Distribution
The high water solubility and moderate molecular weight predict that the substance will distribute widely through the body.
The log Kow value was experimentally determined to be -1.23 (Envigo, 2018) at 21°C and pH 10.9. The substance is not likely to distribute into cells and hence the intracellular concentration is not expected to be higher than the extracellular concentration.
Accumulation
In view of the low log Kow and the high water solubility, the test substance is not expected to accumulate in the body (lung, adipose tissue, stratum corneum).
Metabolism
Once absorbed, extensive hydroxylation (aliphatic carbons) and oxidative deamination (tertiary amines), followed by rapid sulfation or glucuronidation is expected.
Excretion
Given the high water solubility and relatively low to moderate molecular weight, the test substance and its metabolites will be mainly excreted via the urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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