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EC number: 403-360-0 | CAS number: 42405-40-3 BONTRON E-84; E-84
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 April to 28 April 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study report is conducted to OECD and EEC guidelines and contains a statement of GLP compliance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 84/449/EEC
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- EC Number:
- 403-360-0
- EC Name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- Cas Number:
- 42405-40-3
- Molecular formula:
- C30H42O6Zn
- IUPAC Name:
- bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- Details on test material:
- Physical state: white powder
- Analytical purity: not known
- Impurities (identity and concentrations): not known
- Composition of test material, percentage of components: not known
- Lot/batch No.: not known
- Expiration date of the lot/batch: not known
- Storage condition of test material: in a glass container at room temperature in the dark
- Other:
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: 515 to 517.2K
- Boiling point: >538K
- Vapour pressure: <0.00001Pa
- Water solubility (under test conditions): 187 mg/l
- Henry's law constant: Not reported
- log Pow: 2.32 at 18C
- pKa: Not reported
- Stability in water: stable in water
- Stability in light: stable in light
- pH dependance on stability: Not reported
OTHER PROPERTIES (if relevant for this endpoint)
- Results of test for ready biodegradability: 15% biodegradation after 28 days
- Other:
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0.025 - 0.25 μg/mlof test substance in a methanol/ distilled water (50:50) dilution solution.
- Sampling method: 10ml sample made upto volume with methanol/ distilled water (50:50)
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
2.0 g of test material were stirred into 5L of de-ionised water overnight at room temperature. The saturated solution was then filtered through glass fibre paper and diluted to give the anticipated test concentrations of 0.10 to 18.0 mg/l.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus
- Source: Laboratory culture originating from a strain supplied by IRCHA, France
- Age at study initiation (mean and range, SD): young daphnids produced overnight before the test.
- Valve height at study initiation, for shell deposition study (mean and range, SD): Not reported
- Peripheral shell growth removed prior to test initiation: Not reported
- Method of breeding: Not reported
- Feeding during test: None
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not reported
Test conditions
- Hardness:
- Total Hardness ≈ 350 mg/l as calcium carbonate. Although slightly higher than the recommended range for this test, it is not considered to have had any significant effects on the results of the test.
- Test temperature:
- 21 ±1C
- pH:
- pH = 8
- Dissolved oxygen:
- Mean D.O.: 94.58%
- Salinity:
- Sodium content: 43.8 mg/l
- Nominal and measured concentrations:
- Nominal test concentrations: 0.10, 0.18, 0.32, 0.56, 1.0, 1.8, 3.2, 5.6, 10 and 18 mg/l
Measured test concentrations: 0.077, 0.50, 0.45, 0.79, 1.6, 2.8, 4.4, 7.5 and 14 mg/l - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass Jars
- Type (delete if not applicable): not reported
- Material, size, headspace, fill volume: 200ml test solution
- Aeration: None
- No. of organisms per vessel: 20 animals per test vessel
- No. of vessels per concentration (replicates): two
- No. of vessels per control (replicates): two
- Biomass loading rate: 20 ml test solution per organism
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionised laboratory water
- Total organic carbon: mean 4.52 mg/l
- Particulate matter: No information
- Metals: No information
- Pesticides: No information
- Chlorine: mean 0.09 mg/l
- Alkalinity: mean 215.22 mg/l (calcium carbonate)
- Ca/mg ratio: mean Ca: Mg ratio = 16:1
- Conductivity: mean 905.31
- Culture medium different from test medium: No information
- Intervals of water quality measurement: 3 monthly intervals.
OTHER TEST CONDITIONS
- Adjustment of pH: no adjustment
- Photoperiod: 16 h light : 8 h dark
- Light intensity: no information
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : 24 and 48 hours
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.73 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: immobilisation
- Remarks on result:
- other: 95% CL: 0.59 - 0.9 mg/l
- Details on results:
- - Behavioural abnormalities: None
- Observations on body length and weight: N/A
- Other biological observations: None reported
- Mortality of control: N/A
- Other adverse effects control: None reported
- Abnormal responses: None reported
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: None reported
- Effect concentrations exceeding solubility of substance in test medium: None reported - Results with reference substance (positive control):
- No positive control data are included
- Reported statistics and error estimates:
- None reported
Any other information on results incl. tables
Time (h) | EC 50 (mg/l) | 95% confidence limits (mg/l) |
24 | 9.0 | 6.3 - 13 |
48 | 0.73 | 0.59 - 0.90 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 hour EC50 of the test substance to Daphnia Magna is 0.73 mg/l.
- Executive summary:
The acute toxcity to Daphnia magna study was conducted with Daphnia magna under static conditions and with analysis provided by HPLC with a UV-visible detector. Conducted over a 48 -hour exposure period, the test substance achieved an EC50of 0.73 mg/l. Based on these test results, the susbstance is proposed to be classified as very toxic to aquatic species.
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