Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 446-640-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-2004
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- Calculation using regression equations
- GLP compliance:
- yes
- Media:
- soil
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- -0.3
Results: HPLC method
- Details on results (HPLC method):
- The log of the adsorption coefficient (kc) of ucb 22060 was estimated to be
log KOC= -0.3 which is equal to a Koc value of 0.5
using the HPLC method. This value indicates that ucb 22060 will not be absorbed by organic
carbon in soil and that ucb 22060 is very high mobile.
Applicant's summary and conclusion
- Conclusions:
- The log of the adsorption coefficient (kc) of ucb 22060 was estimated to be
log KOC= -0.3 which is equal to a Koc value of 0.5
using the HPLC method. This value indicates that ucb 22060 will not be absorbed by organic
carbon in soil and that ucb 22060 is very high mobile. - Executive summary:
The determination of the adsorption coefficient (Koc) of ucb 22060 was pedormed according to the OECD Guideline for the Testing of Chemicals, No. 121, Estimation of the Adsorption Coefficient (Koc) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), January, 2001 and the EC Directive 2001/59, C.19. The test item solution was injected three times and the combined reference solution was injected six times. The log Koc was calculated using a regression curve (log k’ vs. log Koc) and was found to be -0.3 which is equal to a Koc value of 0.5. In the present study the reference items covered the range of log Koc 1.25 to log Koc 5.63. An example of an HPLC chromatogram of the reference standard mixture is shown in Figure 1. An HPLC chromatogram of a test item solution is shown in Figure 2. A typical chromatogram of the determination of the dead-time is given in Figure 3. The chromatography of the test item resulted in one main peak with a well-defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, ucb 22060 was considered to be stable during the test procedure. The retention times of the individual measurements of the reference items, test item and the dead time are given in Table 1. The capacity factor (k’) was calculated for each reference item using the retention times. Log &c was plotted versus log k for each component to obtain a regression curve (Table 2 and Figure 4). The retention time of ucb 22060 in the HPLC chromatogram is shorter than the retention time of the lowest reference item used. Therefore, the logarithm of the adsorption coefficient of ucb 22060 was extrapolated from the regression curve to be -0.3 (see Table 3). The Koc of ucb 22060 was calculated to be 0.5. The tabulated values represent rounded mean results, which were obtained by calculation using the exact raw data. In conclusion, the log of the adsorption coefficient (Koc) of ucb 22060 was estimated to be log KOC = -0.3 which is equal to a Kocvalue of 0.5 using the HPLC method. This value indicates that ucb 22060 will not be absorbed by organic carbon in soil and that ucb 22060 is very high mobile.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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