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EC number: 205-182-7 | CAS number: 135-19-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The in vivo skin irritation/corrosion study of 2-naphthol was determined in accordance with OECD Test Guideline 404 (Acute Dermal Irritation/Corrosion).
Test Species New Zealand White Rabbit (approx. 3-5 months old).
A patch test was carried out at the dorsal area of the torso after shaving and 500 mg of the test substance was applied per animal for a total exposure time of 4 hours. Assessments were made after 30 min, 60 min, 24 h, 48 h and 72 h after patch removal.
No resulting erythema and no resulting edema were observed at any of the observation time points.
Therefore, there was no skin reaction observed within 72 hours and the test item is classified as not irritating to the skin.
The in vivo eye irritation of 2-naphthol was determined in accordance with OECD Testing Guideline 405 (Acute Eye Irritation/Corrosion).
Test species: New Zealand White Rabbit
100 mg of the test substance 2-naphthol was used on 3 concurrent animals with an observation period of 7 days.
1-72 hours after application: conjunctival swelling (Draize scores 2 and 3), grade 2 conjuctivitis, corneal opacity (grade 1) and iritis (grade 1). White discharge. 1 out of 3 animals was free of symptoms after 7 days. The other two animals showed slight to moderate conjunctivitis, one animal had iritis and white discharge. Both animals had corneal opacities with vascularization and conjunctivae were partly detached.
2-Naphthol induced severe damage to rabbit's eyes in Draize test. According to the CLP regulation, the test item 2-naphthol was defined as Category 1 "Irreversible effects on the eyes" based on GHS criteria.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.08.1986 - 15.08.1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 12.05.1985
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- animal weight: 2,6 - 3,2 kg
animal age: approx. 3 - 5 months
animal keeping: single cages in fully air-conditioned rooms - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Amount / concentration applied:
- 500 mg beta-Naphthol per animal
- Duration of treatment / exposure:
- exposure time: 4 h
- Observation period:
- The assessments were made after 30 min, 60 min., 24 h, 48 h, and 72 h after patch removal.
- Number of animals:
- 3
- Details on study design:
- Patch test was carried out at the dorsal area of the torso after shaving.
- Irritation parameter:
- erythema score
- Basis:
- animal: 1, 2, 3
- Time point:
- other: after 30min. and 60 min.
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: 1, 2, 3
- Time point:
- other: after 30 min. and 60 min.
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- no resulting erythema, no resulting edema
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- During the whole test period no irritations for beta-naphthol on New Zealand rabbits were observed. Therefore, 2-Naphthol is classified as not irritating to the skin.
- Executive summary:
In a study according to OECD Test No. 404 Acute dermal Irritation/corrosion the skin irritation potential of 2-naphthol was evaluated in New Zealand White rabbits. Application of 500 mg was made onto the intact and shaved skin. There was no skin reaction observed within 72 hours. Therefore, the test item is classified as not irritating to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.08.1986 - 19.08.1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 12.05.1981
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- 100 mg per animal
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 3 concurrent animals
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- former R41
- Conclusions:
- Under experimental conditions of this study, the test item 2-Naphthol induced severe damages to rabbit's eyes in a Draize test according OECD Guideline 405 method. According to CLP regulation, the test item 2-Naphthol was defined as Category 1 "Irreversible effects on the eyes" based on GHS criteria.
- Executive summary:
A Draize test according OECD Guideline 405 method was performed to assess the potential irritation/corrosion property of 2-Naphthol.
Under experimental conditions of this study, the test item 2-Naphthol induced severe damages to the rabbits' eyes .
Reference
1 - 72 hours after application: conjunctival swelling (Draize scores 2 and 3), grade 2 conjunctivitis, corneal opacity (grade 1) and irits (grade 1). White discharge. 1 out of 3 animals was free of symptoms after 7 days. The other two animals showed slight to moderate conjunctivitis, one animal had iritis and white discharge. Both animals had corneal opacities with vascularization and conjunctivae were partly detached.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
Justification for classification or non-classification
Skin irritation and eye irritation were investigated in accordance with the relevant OECD Test Guidelines.
2-Naphthol did not result in any erythema or edema during an in vivo skin irritation study. The test substance does not meet the criteria for classification as irritant to the skin according to Regulation EC No. 1272/2008.
2-Naphthol produced severe irreversible damage to rabbit's eyes and was classed as Category 1 eye irritant according to Regulation EC No. 1272/2008.
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