Fatty acids, C8-10 and C18-unsatd., diesters with neopentyl glycol

Short-term toxicity to fish

Description of key information

No effects up to the limit of water solubility for Oncorhynchus mykiss (OECD 203); read-across

Additional information

Since no studies investigating the short-term toxicity to fish of Fatty acids, C8-10 (even numbered) and C16 and C18-unsatd., esters with Neopentylglycol (CAS No. former CAS 85186-86-3) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across to the structurally most similar category members Heptanoic acid, ester with 2,2-dimethyl-1,3-

propanediol (CAS No. 68855-18-5) and Fatty acids, C8-18 and C18-unsatd., esters with neopentyl glycol (CAS No. 85186-86-3) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification in IUCLID section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment by showing a consistent pattern of results.

The key study conducted with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed, according to OECD Guideline 203 and GLP, in a semi-static system, using Oncorhynchus mykiss as test organism (Parr, 2012). During 96 hours, the fish were exposed to the nominal test concentrations of 100% v/v, corresponding to a measured concentration of 0.086 mg/L. This was the highest attainable concentration, due to the poor solubility of the test substance. The test solutions were prepared using a solvent, and undissolved test material was removed by filtration. No mortality occurred during the study, and the LC50 (96 h) was reported to be > 0.086 mg/L.

The key study conducted with Fatty acids, C8-18 and C18-unsatd., esters with neopentyl glycol (CAS No. 85186-86-3) was performed, according to OECD Guideline 203 and GLP, in a semi-static system, using Oncorhynchus mykiss as test organism (Goodband and Mullee, 2012). The fish were exposed to the test substance at the nominal test concentration of 100 mg/L for 96 hours. The test solutions were prepared as water accommodated fractions (WAF). No mortality occurred during the study, and the LC50 (96 h) was reported to be > 100 mg/L.

Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no short-term effects on fish are expected up to the limit of water solubility for Fatty acids, C8-10 (even numbered) and C16 and C18-unsatd., esters with Neopentylglycol. As it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results within the polyol esters category.