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EC number: 603-073-2 | CAS number: 12549-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.5.-11.9.2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was performed by following the recommended methods (Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995) and GLP.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The flask method was used even though the method recommends the column elution method for test items with a solubility < 10 mg/L.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The flask method was used even though the method recommends the column elution method for test items with a solubility < 10 mg/L.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate is included in the study report
- Type of method:
- flask method
- Water solubility:
- <= 0.89 mg/L
- Temp.:
- 20 °C
- pH:
- >= 6.32 - <= 6.48
- Remarks on result:
- other: T = 20.0 ± 0.5 °C
- Details on results:
- The final concentration was calculated based on the iron and cobalt concentrations in the samples:
Concentration Range:
- 4.35 x 10^-4 to 8.90 x 10^-4 g/L based on cobalt solubility
- 1.93 x 10^-4 to 5.32 x 10^-4 g/L based on iron solubility.
Overall Result : ≤ 8.90 x 10^-4 g/L at 20.0 ± 0.5 ºC - Conclusions:
- During the preliminary study the water solubility of the test item was estimated to be 0.558 mg/L. Method A6 Water solubility (440/2008/EC) recommends that the column elution method should be used if the water solubility is < 1x10^-2 g/L. However, since the substance is insoluble in organic solvents, the column elution method could not be applied.
Using the flask method, the water solubility of the test item has been determined to be less than or equal to 8.90 x 10-4 g/L of solution at 20.0 ± 0.5 °C. The substance is therefore poorly soluble in water. - Executive summary:
The water solubility of the substance was determined to be less than or equal to 8.90 x 10^-4 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Reference
The cobalt concentration (g/L) in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30 ⁰C (hours) |
Time Equilibrated at 20 ⁰C (hours) |
Concentration (g/L) |
Mean Concentration (g/L) |
Test Item Mean Concentration (g/L) |
Solution pH |
1A |
24 |
24 |
8.87 x 10^-5 |
8.90 x 10^-5 |
5.27 x 10^-4 |
6.32 |
1B |
24 |
24 |
8.93 x 10^-5 |
|||
2A |
48 |
24 |
1.49 x 10^-4 |
1.50 x 10^-4 |
8.90 x 10^-4 |
6.48 |
2B |
48 |
24 |
1.51 x 10^-4 |
|||
3A 3B |
72 72 |
24 24 |
7.34 x 10^-5 7.34 x 10^-5 |
7.34 x 10^-5 |
4.35 x 10^-4 |
6.33 |
The iron concentration (g/L) in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30 ⁰C (hours) |
Time Equilibrated at 20 ⁰C (hours) |
Concentration (g/L) |
Mean Concentration (g/L) |
Test Item Mean Concentration (g/L) |
Solution pH |
1A |
24 |
24 |
4.83 x 10^-5 |
4.83 x 10^-5 |
3.02 x 10^-4 |
6.32 |
1B |
24 |
24 |
4.83 x 10^-5 |
|||
2A |
48 |
24 |
8.46 x 10^-4 |
8.52 x 10^-4 |
5.32 x 10^-4 |
6.48 |
2B |
48 |
24 |
8.58 x 10^-4 |
|||
3A 3B |
72 72 |
24 24 |
3.03 x 10^-5 3.15 x 10^-5 |
3.09 x 10^-5 |
1.93 x 10^-4 |
6.33 |
Description of key information
Flask method: water solubility less than or equal to 0.89 mg/L at 20 °C (EU Method A6 and OECD 105 with slight deviations, GLP)
Key value for chemical safety assessment
- Water solubility:
- 0.89 mg/L
- at the temperature of:
- 20 °C
Additional information
During the preliminary study the water solubility of the test item was estimated to be 0.558 mg/L. Method A6 Water solubility (440/2008/EC) recommends that the column elution method should be used if the water solubility is < 1x10^-2 g/L. However, since the substance is insoluble in organic solvents, the column elution method could not be applied.
Using the flask method, the water solubility of the test item has been determined to be less than or equal to 8.90 x 10-4 g/L of solution at 20.0 ± 0.5 °C. The substance is therefore poorly soluble in water.
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