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EC number: 268-919-1 | CAS number: 68154-72-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: SOAP012-2
- Expiration date of the lot/batch: 1 November 2022
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Ambient - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < 1
- Temp.:
- 25 °C
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- The soluble components of the test item co-eluted with formamide, therefore it was assumed that the partition coefficients of the soluble components of the test item were less than that of the shortest eluting standard assessed (acetanilide) with a log10 Pow value less than 1.0
- Details on results:
- The soluble components of the test item co-eluted with formamide (Internal deadtime standard (IDS).
It was therefore concluded that although the method was not strictly applicable to the test item, it is logical to assume that the partition coefficients of the soluble components of the test item were less than that of the shortest eluting standard assessed (acetanilide) with a log10Pow value less than 1.0. Furthermore, it could be concluded that the larger molecular weight components, which were not soluble in water, would have much higher Pow values. - Conclusions:
- The soluble components of the test item were determined to have a log10 Pow values less than 1.0. The higher molecular weight components, which were not soluble in water, would have much higher Pow values.
- Executive summary:
A study to determine the partition coefficient of the test item, fatty acids lanolin lithium salts, was conducted according to the OECD 117 guideline (Dunning 2018). The experimental determination of partition coefficient is not applicable to surface active materials; however, an attempt was made to assess the property by the HPLC method since often the retention time of a material can provide a good indication of the partition coefficient. The partition coefficient was determined by the HPLC method. Six reference compounds were selected to have log10 Pow values between 1 and 6.2. An attempt was made to prepare a solution of the test item, however, a solvent was not found which could dissolve the entire test item. Consequently the decision was taken to saturate a portion of water with the test item, recognising that the resulting solution would primarily contain the six components of lowest molecular weight.
The soluble components of the test item co-eluted with the Internal deadtime standard (formamide). It was therefore concluded that the partition coefficients of the soluble components of the test item were less than that of the shortest eluting standard assessed (acetanilide) with a log10 Pow value less than 1.0. Furthermore, it could be concluded that the higher molecular weight components, which were not soluble in water, would have much higher Pow values.
The study is GLP-compliant and was conducted according to the standard guideline, therefore is considered reliable without restrictions and suitable as a key study for this endpoint.
Reference
Description of key information
The soluble components of the test item were determined to have a log10 Pow values less than 1.0. The higher molecular weight components, which were not soluble in water, would have much higher Pow values.
Key value for chemical safety assessment
Additional information
A study to determine the partition coefficient of the test item, fatty acids lanolin lithium salts, was conducted according to the OECD 117 guideline (Dunning 2018). The experimental determination of partition coefficient is not applicable to surface active materials; however, an attempt was made to assess the property by the HPLC method since often the retention time of a material can provide a good indication of the partition coefficient. The partition coefficient was determined by the HPLC method. Six reference compounds were selected to have log10 Pow values between 1 and 6.2. An attempt was made to prepare a solution of the test item, however, a solvent was not found which could dissolve the entire test item. Consequently the decision was taken to saturate a portion of water with the test item, recognising that the resulting solution would primarily contain the six components of lowest molecular weight.
The soluble components of the test item co-eluted with the Internal deadtime standard (formamide). It was therefore concluded that the partition coefficients of the soluble components of the test item were less than that of the shortest eluting standard assessed (acetanilide) with a log10 Pow value less than 1.0. Furthermore, it could be concluded that the higher molecular weight components, which were not soluble in water, would have much higher Pow values.
The study is GLP-compliant and was conducted according to the standard guideline, therefore is considered reliable without restrictions and suitable as a key study for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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