Propanoic acid, 2-hydroxy-, ammonium salt (1:1), (2S)-

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November, 1941

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

Lactic acid had been prepared by the method of Smith and Claborn and an analysis (by a modified Eder and Kutter procedure) gave 60 % “directly titratable acid” and 102.0 % “total acid”, both expressed as lactic acid. It had the following physical properties: refractive index = 1.4361 (25 °C) and relative density = 1.2143 (25 °C).

The saturated Ammonium lactate solution was prepared by passing dry ammonia into lactic acid diluted with about 10 % water. The ammonia was passed in under reflux, until the theoretical amount had been absorbed. At first an odor of ammonia persisted, but this disappeared after the solution had stood in a glass-stoppered bottle for one week. The ammonia content of the solution was determined by Kjeldahl distillation.

GLP compliance:

no

Type of method:

other: Ammonia content determined by Kjeldahl distillation.

Key result

Water solubility:

1 077 g/L

Conc. based on:

test mat. (dissolved fraction)

Remarks on result:

other: Temperature and pH not reported in the literature.

Details on results:

The maximum achievable concentration of Ammonium lactate in water is approximately 90 % (w/w). The water solubility of the substance is reported to be approximately 1077 g/L.

Conclusions:

For determination of the physical-chemical properties of differently concentrated Ammonium lactate solutions, an aqueous stock solution was prepared by passing dry ammonia into lactic acid containing approximately 10 % water. The ammonia was passed in under reflux, until the theoretical amount had been absorbed. At first an odour of ammonia persisted, but this disappeared after the solution had stood in a glass-stoppered bottle for one week. The ammonia content of the solution was determined by Kjeldahl distillation. The maximum achievable concentration of Ammonium lactate in water is approximately 90 % (w/w). The water solubility of the substance is reported to be approximately 1077 g/L.

Executive summary:

For determination of the physical-chemical properties of different concentrated Ammonium lactate solutions, an aqueous stock solution was prepared by passing dry ammonia into lactic acid containing approximately 10 % water. The ammonia was passed in under reflux, until the theoretical amount had been absorbed. At first an odor of ammonia persisted, but this disappeared after the solution had stood in a glass-stoppered bottle for one week. The ammonia content of the solution was determined by Kjeldahl distillation. The maximum achievable concentration of Ammonium lactate in water is approximately 90 % (w/w). The water solubility of the substance is reported to be approximately 1077 g/L.

Reference 2

Endpoint:

water solubility

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

For details and justification of read-across please refer to the report attached in section 13 of IUCLID.

Reason / purpose for cross-reference:

read-across source

Key result

Water solubility:

1 077 g/L

Conc. based on:

test mat. (dissolved fraction)

Remarks on result:

other: Temperature and pH not reported in the literature.

Conclusions:

The water solubility of Ammonium-(S)-lactate is derived by read-across to Ammonium lactate. The chirality of the test item Ammonium lactate used in the experimental study performed by Dietz et al. (1941) was not specifed. However, it is assumed that chirality has only a minor influence on water solubility. Thus, the water solubility of Ammonium-(S)-lactate can also be given as 1077 g/L.

Executive summary:

For determination of the physical-chemical properties of differently concentrated Ammonium lactate solutions, an aqueous stock solution was prepared by passing dry ammonia into lactic acid containing approximately about 10 % water. The ammonia was passed in under reflux, until the theoretical amount had been absorbed. At first an odor of ammonia persisted, but this disappeared after the solution had stood in a glass-stoppered bottle for one week. The ammonia content of the solution was determined by Kjeldahl distillation. The maximum achievable concentration of Ammonium lactate in water is approximately 90 % (w/w). The water solubility of the substance is reported to be approximately 1077 g/L.

This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).

Description of key information

For determination of the physical-chemical properties of differently concentrated Ammonium lactate solutions, an aqueous stock solution was prepared by passing dry ammonia into lactic acid containing approximately 10 % water. The ammonia was passed in under reflux, until the theoretical amount had been absorbed. At first an odour of ammonia persisted, but this disappeared after the solution had stood in a glass-stoppered bottle for one week. The ammonia content of the solution was determined by Kjeldahl distillation. The maximum achievable concentration of Ammonium lactate in water is approximately 90 % (w/w). The water solubility of the substance is reported to be approximately 1077 g/L.

Key value for chemical safety assessment

Water solubility:

1 077 g/L

at the temperature of:

20 °C

Additional information

This information is used in a read-across approach in the assessment of the substance to be registered. For details and justification of read-across please refer to the report attached in section 13 of IUCLID.