Registration Dossier
Registration Dossier
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EC number: 700-100-0 | CAS number: 39716-58-0
Endpoint summary
Administrative data
Description of key information
Studies with 4-Pentenoyl chloride determining the acute oral toxicity were waived according to ANNEX VII colum2 of the REACH regulation: the available information indicates that the criteria for classification of 5-Pentenoyl chloride as corrosive for the skin are met.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 470 mg/kg bw
Additional information
It was agreed with the German competent authority to classify the substance 4-Pentenoyl chloride as corrosive with R35 "Cause severe burns". Therefore no further testing with regard to acute toxicity (oral application) is necessary according to ANNEX VII column 2 of the REACH regulation.
As additional information for the classification of 4-Pentenoyl chloride regarding acute toxicity (oral route) the toxicity of 4-Pentenoic acid was assessed as the main non-corrosive hydrolysis product.
Justification for classification or non-classification
4-Pentenoyl chloride as a carboxylic acid chloride, reacts immediately in an exothermic reaction with water. If applied directly, marked pain, and corrosion of the skin based on a local reaction at the skin can be expected. Using a vehicle like water, the substance will react immediately. With other vehicles (oils) chemical reactions or local reactions cannot be excluded. It was agreed with the German competent authority to classify the substance as corrosive with R35 "Causes severe burns" without any further animal testing.
In addition 4 -Pentenoic acid as the main hydrolysis product has an acute oral LD50 of 470 mg/kg bw. Based on this result the substance 4- Pentenoyl chloride was classified as harmful if swallowed with "R22" .
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