Dimethyl(octyl)amine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 November 2016 to 17 May 2016

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

297.4 mg/L

Temp.:

20 °C

pH:

10.81

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide: Sampling Time 24 h/ Flask 1

Water solubility:

261 mg/L

Temp.:

20 °C

pH:

10.81

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide: Sampling Time 24 h / Flask 2

Water solubility:

224.6 mg/L

Temp.:

20 °C

pH:

10.81

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide: Sampling Time 48 h / Flask 1

Water solubility:

224.6 mg/L

Temp.:

20 °C

pH:

10.81

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide: Sampling Time 48 h / Flask 2

Water solubility:

211.3 mg/L

Temp.:

20 °C

pH:

10.73

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide; Sampling Time 75 h / Flask 1

Water solubility:

197.5 mg/L

Temp.:

20 °C

pH:

10.73

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide; Sampling Time 75 h / Flask 2

Water solubility:

332 mg/L

Temp.:

20 °C

pH:

10.65

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide; Sampling Time 173 h / Flask 1

Water solubility:

298 mg/L

Temp.:

20 °C

pH:

10.65

Remarks on result:

other: Main Test: Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide; Sampling Time 173 h / Flask 2

Key result

Water solubility:

255.8 mg/L

Temp.:

20 °C

pH:

10.75

Remarks on result:

other: Result: Overall Mean; water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide

Details on results:

Calculated Concentration:
Overall Mean 255.8
Standard Deviation:14.9
RSD* [%]:5.8
*RSD – relative standard deviation


pH-value:
Overall Mean: 10.75
Standard Deviation:0.08
RSD* [%]:0.71
*RSD – relative standard deviation

  Preliminary Test:

The results are presented in Table 2 and Table 3.

Table 2:   Preliminary test results in ultra-pure water (1000 g/L to 1 g/L)

Test Item [mg]	total volume of water [mL]	time of shaking [min]	remarks	Approx. solubility [g/L]
100.4	0.10	10	not dissolved completely	< 1000
	0.50	10	not dissolved completely	< 200
	1.0	10	not dissolved completely	< 100
	2.0	10	not dissolved completely	< 50
	10	10	not dissolved completely	< 10
	100	36	not dissolved completely	< 1
	105	10	not dissolved completely	< 1
	105	1440	not dissolved completely	< 1

 

Table 3:   Preliminary test results in ultra-pure water (11.1 g/L to 0.111 g/L)

Test Item [mg]	total volume of water [mL]	time of shaking [min]	remarks	Approx. solubility [g/L]
11.1	1.0	10	not dissolved completely	< 11.1
	2.0	10	not dissolved completely	< 5.55
	10	10	not dissolved completely	< 1.11
	100	10	dissolved	0.111 - 1.11

 

Therefore, the approximate solubility of the test item was estimated to be 0.111 -1.11 g/L at 20 °C.

Main Test:

The results of the two independent flasks are summarized in Table 4.

 

Table 4:   Results of the water solubility of AD 1 in ultra-pure water being in equilibrium with atmospheric carbon dioxide

Sampling	Calculated	Calculated	pH value
Time	Concentration Flask 1	Concentration Flask 2
[h]	[mg/L]	[mg/L]
24	297.4	261.0	10.81
48	224.6	224.6	10.81
75	211.3	197.5	10.73
173	332.0	298.0	10.65
Mean:	266.3	245.3	10.75
Overall Mean	255.8		10.75
Standard Deviation:	14.9		0.08
RSD* [%]:	5.8		0.71

*RSD – relative standard deviation

 

The two independent flasks do not differ by more than 15 % from each other.

Conclusions:

Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The solubility of AD 1 in water was determined in ultra-pure water being in equilibrium with atmospheric carbon dioxide at a temperature of 20 °C. The water was prepared by stirring ultra-pure water at room temperature under atmospheric pressure. The results are presented in the table below:
Solubility of AD 1 in ultra-pure water
pH 10.75
Temperature [°C] 19.8 - 20.1
Solubility [mg/L] 255.8

Executive summary:

Report: Nitzsche, I. (2016): AD1 Water Solubility of AD1

Source: Eurofins Agroscience Services EcoChem GmbH / Eurofins Agroscience Services Ecotox GmbH,Eutinger Straße 24,
D – 75223 Niefern-Öschelbronn, Germany; unpublished Report:S15-05583

Guidelines: EC A. 6 and OECD 105

Deviations: no

GLP: yes (incl. certificate)

Materials and Methods: Flask method

Date of work: 30 November 2016 to 17 May 2016

Results: The solubility of AD 1 in water was determined in ultra-pure water being in equilibrium with atmospheric carbon dioxide at a temperature of 20 °C. The water was prepared by stirring ultra-pure water at room temperature under atmospheric pressure. The results are presented in the table below:

Solubility of AD 1 in ultra-pure water

pH	10.75
Temperature [°C]	19.8 - 20.1
Solubility [mg/L]	255.8

Key value for chemical safety assessment

Water solubility:

255.8 mg/L

at the temperature of:

20 °C