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EC number: 305-230-8 | CAS number: 94350-12-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Saccharomyces cerevisiae, lysate
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- Reference substance:
- Saccharomyces cerevisiae, lysate
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Saccharomyces cerevisiae lysate is readily biodegradable in ready biodegradation test and so it is considered neither persistent nor very persistent.
Due to its very high water solubility, the estimated log Kow of the water soluble fraction of saccharomyces cerevisaie lysate is considered very low and so this fraction is not suspected to be bioaccumulable. The insoluble fraction is made of cell wall and also not suspected of bioaccumulation. Therefore Saccharomyces cerevisiae lysate is neither bioaccumulable, nor very bioaccumulable.
In the acute toxicity tests performed to fish and Daphnia and the toxicity test to the green algae, no toxicity was observed at the loading rate of 100 mg/L (WAF). So Saccharomyces cerevisiae lysate is not toxic to the tested aquatic organisms. Moreover, long-term effects are not expected on populations of aquatic organisms other than potentially providing nutrients. In addition, no toxicity of Saccharomyces cerevisiae or derivatives (yeast, yeast extracts and yeast cell wall fractions), is expected on terrestrial compartments. In the absence of adverse effects, no classification is required for Saccharomyces cerevisiae, lysate. according to CLP.
No data are available to evaluate the carcinogenicity of the substance, hence no classification is determined. The negative results obtained in the three in vitro key studies (Ames, MLA and Micronucleus tests), permit to conclude on a non-potentially mutagenic or genotoxic effect of the substance. Taking together the results of the OECD TG 422 study performed on Saccharomyces cerevisiae, lysate showing no adverse effects on reproductive performance and no effects at the maximum dose tested, with a NOAEL of 1000 mg/kg bw/d, and all the evidence on the long history of safe-use of Saccharomyces cerevisiae yeast and its various derivative substances, it was concluded that Saccharomyces cerevisiae, lysate is not expected to be a reproductive or developmental toxicant. Based on the available data, the substance should not be classified for mutagenicity and reprotoxicity according to CLP. Based on all the reliable repeated dose toxicity data available on the target substance Saccharomyces cerevisiae, lysate as well as on the various Saccharomyces cerevisiae derivative substances or the whole SC yeast organism (ranging from subacute to chronic), no toxicity upon repeated exposure is expected for the registered substance Saccharomyces cerevisiae, lysate. Based on the available data, the substance should not be classified for mutagenicity, reprotoxicity and for repeated toxicity according to CLP.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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