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Diss Factsheets
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EC number: 205-531-3 | CAS number: 142-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- information taken from dermal toxicity study
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- information taken from dermal toxicity study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- GESTIS Substance Database 1,3-Dichloropropane
- Author:
- IFA Institue for Occupational Safety and Health of the German Social Accident Insurance
- Year:
- 2 018
- Bibliographic source:
- http://gestis-en.itrust.de/pdf/create/Data_sheet.php
Materials and methods
- Principles of method if other than guideline:
- Observation from dermal toxicity study: 2000 mg/kg occlusive on the skin for 24 h without effect (post incubation observation period14 d)
- GLP compliance:
- no
- Remarks:
- Reliable data from handbook or collection of data but without specification of method. GLP not specified but quality is assumed to be similar to GLP
Test material
- Reference substance name:
- 1,3-dichloropropane
- EC Number:
- 205-531-3
- EC Name:
- 1,3-dichloropropane
- Cas Number:
- 142-28-9
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,3-dichloropropane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- no data available
In vitro test system
- Vehicle:
- unchanged (no vehicle)
- Amount/concentration applied:
- 2000 mg/kg bw
- Duration of treatment / exposure:
- 24 h
- Duration of post-treatment incubation (if applicable):
- post incubation observation period 14 d
Test animals
- Species:
- rat
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- data available in data bank
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 2000 mg/kg bw
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 14 d
- Number of animals:
- unknown
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: score of up to 10
- Remarks:
- 10 is highest score = corrosive
- Value:
- 2
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Other effects / acceptance of results:
- dernal toxicity test: no fatalities
In vivo
- Irritant / corrosive response data:
- Category 3 (mild irritant) based on GHS criteria
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- Worst case: Category 3 (mild irritant) based on GHS criteria (result to be checked in regard to classification)
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