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EC number: 947-943-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 June 2017 - 18 July 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 13 April 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance document on aquatic toxicity testing of difficult substances and mixtures, OECD series on testing and assessment number 23
- Version / remarks:
- 2000
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of Resin acids and Rosin acids, sodium salts and barium chloride
- Molecular formula:
- not applicable
- IUPAC Name:
- Reaction products of Resin acids and Rosin acids, sodium salts and barium chloride
- Test material form:
- solid: particulate/powder
- Details on test material:
- Name as cited in the report: Barium salts of resin acids and rosin acids
Appearance: light tan powder
Storage conditions: at room temperature desiccated
Constituent 1
- Specific details on test material used for the study:
- Stability in water: stable
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken from each concentration according to the schedule below.
Frequency: at t=0 h and at t=48 h
Volume: 2.0 mL from the approx. centre of the test vessels
Storage: Samples were stored in a freezer (≤ 15°C) until analysis.
At the end of the exposure period, the replicates were pooled at each concentration before sampling.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Direct application to the test medium: preparation of test solutions started with loading rates individually prepared at a range of 1.0 to 100 mg/L. A 3-day period of magnetic stirring was applied to ensure maximum dissolution of the test item in test medium. Subsequently, the aqueous Water Accommodated Fractions (WAFs) were collected by means of filtration through a 0.45 µm membrane filter and used as test concentrations.
- Controls: Test medium without test item or other additives.
- Evidence of undissolved material: All test solutions were clear and colorless at the end of the preparation procedure and no Tyndall effects were observed in the final test, when checking with a laser pen.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia
- Age at study initiation: <24 hours
- Source: in-house laboratory culture with a known history, at least third generation, obtained by a cyclical parthenogenesis under specified breeding conditions. The daphnids originated from a healthy stock, 2nd to 5th brood, showing no signs of stress such as mortality >20%, presence of males, ephippia or discoloured animals and there was no delay in the production of the first brood.
- Age of parental stock: >2 weeks
- Feeding during test: no
BREEDING
- Breeding method: each batch was started with newborn daphnids, i.e. less than 3 days old, by placing about 250 of them into 5 litres of medium in an all-glass culture vessel. Cultures (maximum age of 4 weeks) were renewed after 7 days of cultivation by renewing the medium twice a week.
- Feeding: daily, a suspension of fresh water algae.
- Health during breeding period (any mortality observed): no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 180 mg CaCO3/L
- Test temperature:
- 20 - 21°C
- pH:
- Start: 7.8-7.9
End: 8.1 - 8.2 - Dissolved oxygen:
- Start: 8.6 - 9.0
End: 8.5 - 8.9 - Nominal and measured concentrations:
- Nominal concentrations: WAFs prepared at loading rates of 4.6, 10, 22, 46 and 100 mg/L
Mean measured concentration: 2.4, 7.6, 15, 26 and 41 mg/L in WAFs prepared at loading rates of 4.6, 10, 22, 46 and 100 mg/L, respectively.
At the start of the test, the actual test concentrations were 2.5, 8.6, 16, 31 and 48 mg/L in WAFs prepared 4.6, 10, 22, 46 and 100 mg/L, respectively. These concentrations decreased to 73-93% of the initial concentrations at the end of the test. Therefore, the mean measured concentrations were calculated. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 60 mL, all-glass vessels, open, fill volume: 50 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water purified by Reverse Osmosis
- Culture medium different from test medium: yes, M7 medium
- Intervals of water quality measurement: at t=0 h and at t=48 h (dissolved oxygen and pH measurements)
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours daily
EFFECT PARAMETERS MEASURED: immobility at t=24 and t=48 hours
COMBINED LIMIT/RANGE-FINDING STUDY
- Test concentrations: WAFs prepared at loading rates of 1.0, (ten daphnids) 10 (ten daphnids) and 100 mg/L (twenty daphnids)
- Results used to determine the conditions for the definitive study: yes, at t=24 and t=48 all daphnids were immobilised at the highest test concentration and at t=48 hours 3 out of 10 daphnids were immobilised. Based on these results, the EC50 was expected to be between 10 and 100 mg/L. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (June 2017)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 9.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CI: 8.0-11 mg/L
- Details on results:
- - Abnormalities observed: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no, the test solutions were observed with a laser pen for a Tyndall effect which had a negative result. Also, microscopic observations showed that the test item did not stick to the daphnids. - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Concentrations tested: 0.10, 0.18, 0.32, 0.56, 1.0 and 1.8 mg/L
- Relevant effect levels: 48h-EC50: 0.59 mg/L, 95% CI: 0.52-0.66 mg/L
- Other: the results where within the expected range according to the historical data (>0.3 and <1.0 mg/L) - Reported statistics and error estimates:
- The 24 and 48h-EC50-values were calculated using the Spearman-Karber method (without trim) on the percentages of affected daphnids and the logarithms of the corresponding average test item concentrations.
ToxRat Professional v 3.2.1 (ToxRat Solutions® GmbH, Germany) was used to perform the analyses.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- see 'overall remarks'
- Conclusions:
- The 48h-EC50 for Daphnia magna exposed to Barium salts of resin acids and rosin acids was 9.3 mg/L based on average exposure concentrations.
- Executive summary:
In a short-term toxicity test, performed according to OECD guideline 202 and GLP principles, Barium salts of resin acids and rosin acids was assessed for its potential toxicity towards Daphnia magna. Twenty daphnids were exposed to each concentration under static conditions for 48 hours. Since the test item was poorly soluble, WAFs were individually prepared at loading rates of 4.6, 10, 22, 46 and 100 mg/L. Samples were taken from each concentration at the start and at the end of the test for analysis, which showed that the measured concentrations decreased 73 -93% of the initial concentrations measured at samples taken from t=0. Based on these results, the geometric mean exposure concentration were calculated to be 2.4, 7.6, 15, 26 and 41 mg/L.
Incidence of immobility was recorded at t=24 and t=48. The 48h-EC50 for Daphnia magna exposed to Barium salts of resin acids and rosin acids was determined to be 9.3 mg/L based on the geometric mean of measured concentrations.
The acceptability criteria were met and the study was considered to be valid.
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