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Diss Factsheets
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EC number: 294-304-2 | CAS number: 91697-43-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 20- 22 Jan 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study, tested with the source substance isopropyl palmitate (CAS 142-91-6). According to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Isopropyl palmitate
- EC Number:
- 205-571-1
- EC Name:
- Isopropyl palmitate
- Cas Number:
- 142-91-6
- Molecular formula:
- C19H38O2
- IUPAC Name:
- isopropyl palmitate
- Details on test material:
- - Name of test material (as cited in study report): Isopropylpalmitate
- Physical state: clear liquid
- Analytical purity: 94.3%
- Impurities (identity and concentrations): C-chain distribution
- Lot/batch No.: 27043
- Expiration date of the lot/batch: February 1999
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 1000 and 3000 mg/L
- Sampling method: at 0, 24 and 48 hours
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 1000 and 3000 mg were weighed into medium and stirred for 24 hours, after two hours of rest an oily film was developed, the clear part of this solution was carefully removed and used for testing
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: BioInternational B.V.,NJ Horn, The Netherlands
- Age at study initiation: 6 - 24 hours
- Feeding during test: none
ACCLIMATION
- Acclimation conditions: M4 medium, 20°C, 900 Lux, 16/8 hours light/darkness regime
- Type and amount of food: Spirulina
- Feeding frequency: daily, last feed 4.5 hours prior to testing
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 19.5 - 20.1 °C
- pH:
- 8.0 - 8.1
- Dissolved oxygen:
- 99 - 101% satuaration
- Nominal and measured concentrations:
- Nominal: control, 1000 and 3000 mg/L
Measured after 0 hours: control, 0.72 and 1.68 mg/L
Measured after 24 hours: control, 0.30 and 2.35 mg/L
Measured after 48 hours: control, 0.08 and 0.41 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL beakers
- Type (delete if not applicable): closed with watch glasses
- Material, size, headspace, fill volume: 50 mL test solution
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 2
OTHER TEST CONDITIONS
- Photoperiod: 16/8 hours light/darkness
- Light intensity: 900 Lux
EFFECT PARAMETERS MEASURED: immobility after 24 and 48 h
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 3 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: separated water phase
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50/LC50: EC50(24h)=1.5 mg/L
Any other information on results incl. tables
No immobilisation occurred at any concentration (0%), however daphnids swam at the surface in concentrations 1000 and 3000 mg/L after 24 and 48 hours. Only the dissolved material was applied to avoid physical influence of the test substance. Analytical retrieval of solved substance were below 0.1%.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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