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Diss Factsheets
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EC number: 443-930-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11-28 to 2006-02-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to standard test guidelines (OECD, EC) and conform GLP requirements. The results can be considered reliable without restriction.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): TIC2782 (T002907)
- Physical state: white solid
- Analytical purity: 99.9%
- Lot/batch No.: 00467090 (= charge 05C0836)
- Expiration date of the lot/batch: 2006-05-04
- Stability under test conditions: unknow
- Storage condition of test material: at room temperature (~20°C), away from direct sunlight
- solubility in water: 32 g/L - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source: predominantly domestic wastewater treatment plant, ARA Ergolz II, Füllinsdorf, Switzerland
- Preparation of inoculum for exposure:
* Washing procedure: The sludge was washed twice with tap water by centrifugation and the supernatant liquid phase was decanted. A homogenized
aliquot of the final sludge suspension was weighed, dried, and the ratio wet to dry weight was calculated.
* Based on the wet to dry weight ratio, calculated amounts of sludge were suspended in test water at 4 g dw/L. During holding prior to use, sludge was aerated at room temperature until use.
* Prior to use, sludge was diluted with test water to 1 g dw/L for use as inoculum.
- Initial biomass concentration in test: 30 mg dw/L test medium - Duration of test (contact time):
- 28 d
- Initial conc.:
- 101 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: test water prepared according to test guidelines.
- Additional substrate: no
- Test temperature: 22°C
- pH: 7.1-7.6, measured prior to testing in each test flask before addition of inoculum, and again in each test flask at the end of the incubation period
- pH adjusted: yes, from 7.8 to 7.4 with a diluted HCL solution
- Suspended solids concentration: intially 30 mg dw/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 500-mL Erlenmeyer flasks , fill-volume 250 mL, SAPROMAT D12 (Voith GmbH, Heidenheim, Germany)
- Number of culture flasks/concentration: 2
- Oxygen consumption was recorded manually by taking a daily reading at least on working day.
- Measuring equipment: by electro-chemical analysis process.
- Test performed in open system: not stated
CONTROL AND BLANK SYSTEM
- Inoculum control: yes, two replicates without test substance with inoculum
- Abiotic sterile control: one replicate poisoned with mercury dichloride at a concentration of 10 mg/L, without inoculum
- Toxicity control: yes, one replicate with test substance, reference substance, and inoculum
- Procedure control: yes, 2 replicates with reference substance and inoculum - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- other: BOD/ThOD
- Value:
- 3
- Sampling time:
- 28 d
- Details on results:
- Points of degradation plot (test substance):
0 % degradation after 1 d
0 % degradation after 3 d
0 % degradation after 4 d
0 % degradation after 5 d
0 % degradation after 6 d
0 % degradation after 7 d
0 % degradation after 8 d
0 % degradation after 11 d
.5 % degradation after 12 d
.5 % degradation after 13 d
.5 % degradation after 14 d
.5 % degradation after 15 d
1.5 % degradation after 18 d
1.5 % degradation after 19 d
1.5 % degradation after 20 d
1.5 % degradation after 21 d
2 % degradation after 22 d
2 % degradation after 25 d
2 % degradation after 26 d
3 % degradation after 27 d
3 % degradation after 28 d - Results with reference substance:
- Average % degradation 93% by exposure day 28, confirming suitability of the activated sludge.
Points of degradation plot (reference substance):
8.5 % degradation after 1 d
63.5 % degradation after 3 d
69 % degradation after 4 d
74 % degradation after 5 d
77.5 % degradation after 6 d
80 % degradation after 7 d
82.5 % degradation after 8 d
86 % degradation after 11 d
87 % degradation after 12 d
88.5 % degradation after 13 d
89 % degradation after 14 d
89 % degradation after 15 d
90 % degradation after 18 d
90 % degradation after 19 d
90.5 % degradation after 20 d
91.5 % degradation after 21 d
91.5 % degradation after 22 d
91.5 % degradation after 25 d
92.5 % degradation after 26 d
93 % degradation after 27 d
93 % degradation after 28 d - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- This study determined the ready biodegradability of T002907 in a 28-day manometric respirometry test according to OECD guideline 301F in the presence of activated sludge (30mg SS/L) from a waste water treatment plant treating mainly domestic sewage. The test substance was found to not be biodegradable under the test conditions. The results of the test can be considered reliable without restriction.
Reference
Description of key information
One study (Grützner, 2006) is included in this dossier and regarded as a key study (Klimisch score of 1). The biodegradability of T002907 was determined according to OECD Guideline 301F and EU Method C.4-D. Under the conditions of the test, T002907 was determined to be not biodegradable within 28 days.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.