Barium dilaurate

Endpoint summary

Description of key information

No acute toxicity studies with barium dilaurate are available, thus the acute toxicity will be addressed with existing data on the dissociation products barium and laurate.

Three studies with the assessment entity barium are available and used in a weight of evidence approach resulting in a LD50>100 and <300 mg/kg bw. The assessment entity laurate does not show signs of acute oral toxicity in experimental testing (LD50 > 2000mg/kg).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Barium

Acute oral toxicity

There are three reliable studies for acute oral toxicity testing (Müller, 1983, Borzelleca, 1988 and Tardiff, 1980). All studies are used in a weight of evidence approach. The study performed by Müller, 1983 results in an LD50of 645 mg BaCl2/kg bw (male/female), the study performed by Borzelleca in 1988 leads to an LD50>100 and <300 mg/kg bw, whereas the study conducted by Tardiff 1980 results in an LD50 of 300 mg/kg bw.

Laurate

According to the HERA document on fatty acid salts (2002) “the available data for fatty acids provide a clear picture of low acute toxicity for this class of chemicals. All oral LD50values were greater than 2,000 mg/kg, with little mortality being observed even at the highest doses tested in the studies (IUCLID, 2000c, 2000e, 2000f, 2000g; Clayton & Clayton, 1982; CIR, 1987) (HERA, 2002).

“In an OECD TG 401 study, a group of five rats/sex was administered dodecanoic acid at a dose of 5000 mg/kg bw. There were no deaths. Transient slight piloerection was observed. At necropsy, stomach mucous membrane appeared slightly reddened. The LD50was > 5000 mg/kg bw (OECD SIDS, 2014)

“International-BioResearch (1974, as referred to by CIR, 1987) determined the acute oral toxicity in groups of five male albino rats. Animals were administered by gavage lauric-, myristic-, palmitic- or stearic acid with increasing doses of up to 10,000 mg/kg bw and oleic acid up to 20,000 mg/kg bw. It was observed that for all these fatty acids the LD50value was above the maximum level tested. Therefore, the EFSA Panel noted that lauric acid and the other fatty acids have a low acute toxicity” (EFSA ANS Panel, 2017).

Barium dilaurate

Three studies with the assessment entity barium are available and used in a weight of evidence approach resulting in a LD50>100 and <300 mg/kg bw. The assessment entity laurate has not shown signs of acute oral toxicity in experimental testing (LD50 > 2000mg/kg).

The calculated acute oral toxicity for barium dilaurate as category 4 for acute oral toxicity is in line with the legally binding harmonised classification of barium salts ((EC) No 1272/2008; Index No. 056-002-00-7).

Justification for classification or non-classification

The LD50 for barium dilaurate is LD50≥340 mg/ kg bw, hence the substance is classified as acute toxic via the oral route Category 4 according to the Regulation (EC) 1272/2008 (Cat.4; H302).