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EC number: 220-410-5 | CAS number: 2756-56-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: read-across from a guideline study
- Justification for type of information:
- The micro-organism toxicity of Isobornyl propionate is based on read-across from Isobornyl acetate. The documentation is presented in the Aquatic Endpoint summary. The accompanying files are also attached there.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 69.6 mg/L
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Effect value from the source chemical was recalculated based on Log Kow and molecular weight for the target chemical.
- Validity criteria fulfilled:
- yes
- Remarks:
- The information is based on read across. The read across rationale is documented according to Annex XI criteria.
- Conclusions:
- Isobornyl propionate has a NOEC for Isobornyl propionate of 69.6 mg/l, based on a conversion from Isobornyl acetate for which a NOEC of 100 mg/l was derived in a ready biodegradation test.
- Endpoint:
- activated sludge respiration inhibition testing
- Remarks:
- biodegradation study, measuring oxygen consumption
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Dec 1996 to 17 Jan 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The information is used for read across to Isobornyl propionate.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source of activated sludge: A biological wate water treatment plant treating predominantly domestic sewage (City of Geneva, Aïre).
- Pretreatment: The sludge is collected in the morning, washed three times in the mineral medium (by centrifuging at 1000 g for 10 minutes, discarding the supernatant and resuspending in mineral medium) and kept aerobic until being used on the same day.
- Preparation of dry weight of suspended solids: The dry weight of suspended solids is determined by taking two 50 mL samples of the homogenised sludge, evaporating water on a steam bath, drying in an oven at 105 - 110 °C for two hours and weighing the residue. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 28 d
- Test temperature:
- 22 °C
- pH:
- - Start all media: 7.39 - 7.44
- End control flasks: 7.46 - 7.66
- End test substance flasks: 7.35 - 7.41
- End reference substance flasks: 7.80 - 8.00 - Nominal and measured concentrations:
- - Nominal concentration: 0 (control) and 100 mg/L
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- TOXICITY
The test substance did not inhibit the intrinsic respiration of the inoculum at the test concentration (see 'Any other information on results incl. tables') and was therefore considered to be non-toxic to the inoculum at the test concentration. Also the results obtained with the reference substane (sodium benzoate) in combination with the test substance show no toxic effect on the micro-organisms. - Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC-value for microorganisms in activated sludge, based on the results of a ready biodegradation study (OECD TG 301F), is 100 mg/L.
- Executive summary:
The toxicity of the substance to microorganisms was determined in a ready biodegradability study according to OECD TG 301F and in compliance with GLP criteria. In this study, activated sludge from predominantly domestic sewage was exposed to 100 mg/L test substance. The test substance did not inhibit the endogenous respiration of the inoculum and was found to be readily biodegradable. Therefore, the test substance was considered to be non-toxic to the inoculum. Based on these findings, the NOEC for microorganisms is 100 mg/L.
Referenceopen allclose all
Table: Biological demand of the test substance (BOD, mg O2/L, adjusted to nominal concentrations
|
Days |
3 |
7 |
13 |
14 |
21 |
28 |
|
BOD Sludge |
replicate 1 |
B1 |
16.0 |
23.0 |
28.0 |
31.0 |
37.0 |
42.0 |
replicate 2 |
B2 |
16.0 |
23.0 |
27.0 |
30.0 |
37.0 |
44.0 |
|
mean |
B |
16.0 |
23.0 |
27.5 |
30.5 |
37.0 |
43.0 |
|
BOD test substance |
replicate 1 |
C1 |
80.9 |
169.1 |
222.0 |
225.9 |
236.7 |
239.6 |
replicate 2 |
C2 |
76.8 |
174.3 |
224.1 |
228.2 |
236.3 |
240.4 |
|
replicate 1 corrected |
C1-B |
64.9 |
146.1 |
194.5 |
195.4 |
199.7 |
196.6 |
|
replicate 2 corrected |
C2-B |
60.8 |
151.3 |
196.6 |
197.7 |
199.3 |
197.4 |
|
% Degradation |
replicate 1 |
D1 |
25 |
56 |
75 |
75 |
77 |
75 |
replicate 2 |
D2 |
23 |
58 |
75 |
76 |
76 |
76 |
|
mean |
D |
24 |
57 |
75 |
75 |
76 |
75 |
Calculations:
B1, B2, C1, C2: experimental O2 uptake values
B = (B1 + B2) / 2
D1 = 100 * (C1 – B) / ThoD * [S]
D2 = 100 * (C2 – B) / ThoD * [S]
D = (D1 + D2)/2
[S]: Initial test substance concentration (mg/L)
ThOD test substance = 2.61 mg O2/mg
Table: Biological demand of the reference substance (BOD, mg O2/L, adjusted to nominal concentrations
|
Days |
5 |
7 |
10 |
14 |
21 |
28 |
|
BOD Sludge |
replicate 1 |
B1 |
22.0 |
23.0 |
26.0 |
31.0 |
37.0 |
42.0 |
replicate 2 |
B2 |
22.0 |
23.0 |
24.0 |
30.0 |
37.0 |
44.0 |
|
mean |
B |
22.0 |
23.0 |
25.0 |
30.5 |
37.0 |
43.0 |
|
BOD reference substance |
replicate 1 |
A1 |
143.0 |
152.9 |
164.9 |
172.9 |
184.9 |
195.9 |
replicate 2 |
A2 |
136.0 |
145.0 |
154.9 |
163.9 |
171.9 |
178.9 |
|
replicate 1 corrected |
A1-B |
121.0 |
129.9 |
139.9 |
142.4 |
147.9 |
152.9 |
|
replicate 2 corrected |
A2-B |
114.0 |
122.0 |
129.9 |
133.4 |
134.9 |
135.9 |
|
% Degradation |
replicate 1 |
D1 |
73 |
78 |
84 |
86 |
89 |
92 |
replicate 2 |
D2 |
68 |
73 |
78 |
80 |
81 |
82 |
|
mean |
D |
71 |
76 |
81 |
83 |
85 |
87 |
Calculations:
B1, B2, A1, A2: experimental O2 uptake values
B = (B1 + B2) / 2
D1 = 100 * (A1 – B) / ThoD * [S]
D2 = 100 * (A2 – B) / ThoD * [S]
D = (D1 + D2)/2
[S]: Initial reference substance concentration (mg/L)
ThOD reference substance = 1.67 mg O2/mg
Description of key information
Isobornyl propionate and micro-organism toxicity
The micro-organism toxicity of the Isobornyl propionate is 69 mg/l, respectively. These are converted values from Isobornyl acetate based on the difference in Log Kow and molecular weight (Log EC in mmol target= Log ECmmol x log Kow source/Log Kow target)
Isobornyl acetate and micro-organism toxicity
Isobornyl acetate's (CAS 125 -12 -2) toxicity to microorganisms was determined in a ready biodegradability study according to OECD TG 301F and in compliance with GLP criteria. In this study, activated sludge from predominantly domestic sewage was exposed to 100 mg/L test substance. The test substance did not inhibit the endogenous respiration of the inoculum and was found to be readily biodegradable. Therefore, the test substance was considered to be non-toxic to the inoculum. Based on these findings, the NOEC for microorganisms is 100 mg/L. The toxicity of the source chemical was converted towards the target substance based on the difference in Log Kow and molecular weight.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 69.6 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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