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EC number: 434-600-2 | CAS number: 2628-16-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 434-600-2
- EC Name:
- -
- Cas Number:
- 2628-16-2
- Molecular formula:
- CH3CO2C6H4CH=CH2
- IUPAC Name:
- 4-ethenylphenyl acetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- maize oil
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 732 mg/kg bw
- 95% CL:
- 1 323 - 2 140
- Remarks on result:
- other:
- Remarks:
- Slope of the mortality curve: 67
- Mortality:
- Male: 700 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 1429 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 2041 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 700 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1429 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 2041 mg/kg bw; Number of animals: 5; Number of deaths: 2 - Clinical signs:
- Signs of toxicity related to dose levels:
Animals died at dosages of 1000 mg/kg or above. The deaths occurred on Days 1,2 or 3. Ante mortem signs comprised lethargy, decreased motor activity, staggering gait, muscle tremor, bradypnoea, tachypnoea, hyperpnoea, hypopnoea, piloerection, ungroomed appearance, closed eyes, cold to the touch, hunched posture and prone position.
Signs of reaction in surviving animals treated at 1000 mg/kg or above comprised lethargy, decreased motor activity, bradypnoea, tachypnoea, hyperpnoea, hypopnoea, râles, pigmented orbital secretion, staggering gait, piloerection, ungroomed appearance, cold to the touch, hunched posture, thin body conformation and prone position. Signs at 700 mg/kg were confined to salivation for 30 minutes after dosing in one male animal.
The surviving animals were overtly normal on Day 6, apart from two male and two female animals treated at 1429 mg/kg which showed thin body conformation or râles from Day 8 to Day 14 and a male treated at 2041 mg/kg which showed bradypnoea and hyperpnoea on Days 5 to 8.
The overall bodyweight gains of surviving animals treated at 1000 mg/kg or above were generally less than that expected for rats of this age and strain. The magnitude of the effect was broadly dosage-related in degree. One female treated at the highest dosage (2041 mg/kg) lost bodyweight (22 g) during the second week of the observation period. - Gross pathology:
- Effects on organs:
Necropsy of the decedents revealed altered stomach contents and occasional observations of dark thymus, dark areas on the gastric mucosa and body surface staining.
Necropsy of the surviving animals was unremarkable.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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