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Diss Factsheets
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EC number: 202-723-9 | CAS number: 99-04-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Reliable and GLP-conform acute toxicity studies of m-toluic acid are available for algae, daphnia, and fish. Algae appear to be most sensitive; the 72-h EC50 for P. subcapitata amounts to 18 mg/L. A 48-h EC50 of 75 mg/L was derived for the immobilisation of Daphnia magna and a 96-h LC50 of 82 mg/L for fish (Oryzias latipes).
Regarding chronic toxicity, reliable and GLP-conform studies are available for algae (P. subcapitata) and daphnids (D. magna). A 72-h NOEC of 10 mg/L based on the inhibition of algal growth rate and a 21-d NOEC of 9.7 mg/L for reproduction for daphnids were determined. According to the QSAR-based outcome of the model ECOSAR v.2.0, m-toluic acid has a very low potential for chronic toxicity to freshwater and saltwater fish since the chronic values (ChV = 10^([log (LOEC x NOEC)]/2)) for freshwater and saltwater fish are with 47.9 mg/L and 82.9 mg/L, respectively, well above the OECD limits of aquatic chronic toxicity tests. Thus, the aquatic invertebrates appear to be most sensitive, and the respective NOEC value is applied in the Chemical Safety Assessment.
Regarding aquatic microorganisms, the 3-h EC50 for the inhibition of respiration of activated sludge is above the highest test concentration of 1000 mg/L. The corresponding EC10 was estimated with 543 mg/L (nominal).
In sum, m-toluic acid has a low potential for acute and chronic aquatic toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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