Registration Dossier
Registration Dossier
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EC number: 264-776-4 | CAS number: 64325-78-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-01-17 to 2018-02-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- column elution method
- Water solubility:
- 0.14 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 2 h
- Temp.:
- 20 °C
- pH:
- ca. 6.8
- Conclusions:
- The water solubility of the test item was found to be 0.14 mg/L at pH 6.8 and a temperature of 20 °C.
- Executive summary:
The water solubility of the test item was determined in distilled water according to the "column elution method" described in the European Commission Council regulation (EC) No 440/2008, Annex, Part A, A.6., OECD-guideline 105 and the EPA Product Properties Test Guideline OCSPP 830.7840 and found to be 0.14 mg/L at pH 6.8 and a temperature of 20 °C.
Reference
Run 1: Regarding fractions 06 to 15 the solubility varied between 0.115 mg/L and 0.177 mg/L. Average solubility: 0.156 mg/L (RSD: 13.0%)
Table 1 Column elution method, Run 1 (25 mL/h); Test material used for coating: 51.72 mg
| Fraction no. | Approx. volume (mL) | pH | Cs (mg/L) |
| Fraction 06 | 15.0 | 7.4 | 0.142 |
| Fraction 07 | 15.5 | 7.1 | 0.158 |
| Fraction 08 | 14.5 | 6.8 | 0.169 |
| Fraction 09 | 14.5 | 6.7 | 0.167 |
| Fraction 10 | 15.0 | 6.6 | 0.131 |
| Fraction 11 | 14.5 | 6.6 | 0.157 |
| Fraction 12 | 15.5 | 6.5 | 0.177 |
| Fraction 13 | 14.5 | 6.9 | 0.168 |
| Fraction 14 | 15.0 | 6.8 | 0.115 |
| Fraction 15 | 15.5 | 6.6 | 0.172 |
Run 2: Regarding fractions 06 to 15 the solubility varied between 0.097 mg/L and 0.154 mg/L. Average solubility: 0.121 mg/L (RSD: 14.5%)
Table 2 Column elution method, Run 2 (12.5 mL/h); Test material used for coating: 51.30 mg
| Fraction no. | Approx. volume (mL) | pH | Cs (mg/L) |
| Fraction 06 | 14.0 | 6.8 | 0.113 |
| Fraction 07 | 14.5 | 6.8 | 0.112 |
| Fraction 08 | 14.5 | 6.8 | 0.147 |
| Fraction 09 | 14.5 | 6.7 | 0.097 |
| Fraction 10 | 14.0 | 6.8 | 0.105 |
| Fraction 11 | 14.5 | 7.0 | 0.154 |
| Fraction 12 | 15.5 | 6.7 | 0.117 |
| Fraction 13 | 14.5 | 6.9 | 0.120 |
| Fraction 14 | 14.0 | 6.9 | 0.123 |
| Fraction 15 | 14.5 | 6.6 | 0.128 |
The determined water solubilities for RUN 1 and RUN 2 show a repeatability of < 30 %, therefore the results of the two runs are considered to be in accordance. At the end of each column elution experiment, there was still enough test item left on the surface of the glass beads at the end of all runs. There were no visible change in the coating during the runs.
Description of key information
The water solubility of the test item was found to be 0.14 mg/L at pH 6.8 and a temperature of 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.14 mg/L
- at the temperature of:
- 20 °C
Additional information
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