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EC number: 237-722-2 | CAS number: 13943-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 January - 27 January, 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Limited information about substance identity and no GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- first version 1981.
- Deviations:
- yes
- Remarks:
- Occlusive instead of semi-occlusive, but not considered to have affected the reliability.
- GLP compliance:
- no
- Remarks:
- performed before GLP was in place in the EU.
Test material
- Reference substance name:
- Tetrasodium hexacyanoferrate
- EC Number:
- 237-081-9
- EC Name:
- Tetrasodium hexacyanoferrate
- Cas Number:
- 13601-19-9
- Molecular formula:
- C6FeN6.4Na
- IUPAC Name:
- tetrasodium hexacyanoferrate
- Test material form:
- solid
- Details on test material:
- - Physical appearance: light yellow powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14, Germany
- Age at study initiation: 5 months
- Weight at study initiation: 2.2 - 2.4 kg (males and females)
- Housing: Single in stainless steel cages modell Asta
- Diet (e.g. ad libitum): standard rabbit diet (Altromin R)
- Water: Free access to tap water
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1
- Humidity (%): 50 - 60
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g moistened with 0.15 mL Aqua dest - Duration of treatment / exposure:
- 4h
- Observation period:
- 1, 24, 48 and 72 hours
- Number of animals:
- 3
- Details on study design:
- STUDY DESIGN
The test substance was applied under a 6.25 cm2 patch to intact skin on each animal. The patches were covered by an overlapping patch of adhesive plastic. The whole area was then bound by occlusive tape (Acrylastic, Beiersdorf and Co.) wrapped round the entire trunk of the animal.
TEST SITE
The rabbits were prepared by shaving the skin of the back free of hair. The left and right site of the back were split up in four patch test areas and two areas were abraded.
SCORING SYSTEM:
The irritation scores were recorded.The irritation was assessed according to OECD 404.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- The test substance caused no erythema and no edema at any time point on the intact skin test sites.
- Other effects:
- No signs of systemic intoxication were observed during the study period.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to Regulation (EC) 1272/2008
- Conclusions:
- In a skin irritation study with rabbits, performed equivalent or similar to OECD 404 guideline, no irritation was observed.
- Executive summary:
In a skin irritation study performed according to OECD test guideline 404, the substance (0.5 g) was applied onto the shaved skin of three rabbits using occlusive dressings for 4 hours. Under the conditions of this study, no irritation was observed for 72 hours. The test substance caused no erythema and no edema on the intact skin test sites. No signs of systemic intoxication were observed during the study period.
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