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EC number: 607-240-0 | CAS number: 23511-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 April - 2 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: from freshly prepared medium and from aged medium after 24 hours
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A water soluble fraction (WSF) was prepared. The test item was dispersed in test water and the dispersion was homogenized with an ultraturrax 15 minutes with 17000 rpm at room temperature.Subsequently the undissolved particles were removed by membrane filtration (membrane filter 0.45 μm, RC).
The filter was saturated in order to avoid adsorption during the filtration. To achieve this, the first 50 ml filtrate were discarded. Then, the filtration was interrupted for ca. 15 minutes to allow adsorption and saturation of the filter material with dissolved test item. Thereafter, the filtration was continued. The next 50 ml were discarded. During filtration the filter was always be kept covered. The following filtrate, i.e. the water soluble fraction, was used in the test. This preparation procedure was carried out for each test media renewal. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: All fish used in the test was gained at Noack Laboratorien GmbH from a single brood stock (supplier: Umweltbundesamt, Schichauweg 58, D-12307 Berlin)
-- Maintenance of the brood fish: Holding was performed at the test facility at 23 ± 2 °C and diffuse light (7 - 750 Lux, natural photoperiod). The water was changed at least once per week.
ACCLIMATION
- Acclimation period: 12 d
- Acclimation conditions (same as test or not): same
- Type and amount of food during acclimation: Sera Vipan (SERA GMBH, Heinsberg, Germany)
- Feeding frequency during acclimation: 3 times per week, 4 % of the fish body weight per feeding day. The test fish were not be fed 24 h before test start.
- Health during acclimation (any mortality observed): no mortality observed - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 60 mg/L as CaCQ3
- Test temperature:
- 22.2 - 23.0 °C
- pH:
- 7.44 - 7.81
- Dissolved oxygen:
- 90-100% saturation
- Nominal and measured concentrations:
- Nominal test substance concentration: 100 mg/L (WSF)
Measured test substance concentration: at test start: 1.12 mg/L (1.1% of nominal), after 24 h: 0.517 mg/L (0.5% of nominal)
Geometric mean measured concentration: 0.340 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria (13 L)
- Type (delete if not applicable): loosely covered with a glass lid.
- Size, fill volume: 25.5/18/28 cm, 10 L
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): every 24 h
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates):2
- Biomass loading rate: 0.07 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap water of local origin was used for holding. The water was filtered on activated charcoal and aerated for at least 24 h to remove chlorine.
OTHER TEST CONDITIONS
- Photoperiod: 16:8 h day-night regime
- Light intensity: 7 - 750 Lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality or symptoms of intoxication after 2, 24, 48, 72 and 96 h
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 0.34 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: no
- Mortality of control: no - Sublethal observations / clinical signs:
Cumulative Mortality [%] in the Test Vessels
Geometric mean
measured
concentration
[mg/L]
Cumulative mortality at observation time [hours
2
24
48
72
96
0.340
0
0
0
0
0
Control
0
0
0
0
0
Reference
Description of key information
No toxic effects on fish up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
The acute toxicity of 2-Phenoxyethyl octanoate (CAS 23511-73-1) to fish was tested in a semi-static limit test according to OECD 203. Zebra fish (Danio rerio) were exposed to a nominal test substance concentration of 100 mg/L (nominal, WSF) for 96 hours. The test medium was renewed every 24 hours. The geometric mean measured test substance concentration was 0.34 mg/L. The mortality of the test fish was determined after 2, 24, 48, 72 and 96 hours. Mortality or symptoms of intoxication were not observed. The reported LL50(96h) value is > 0.34 mg/L (geom. mean, WSF).
Based on the available acute toxicity data toxic effects of the substance 2-Phenoxyethyl octanoate are not expected.
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