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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
60to 10th september 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The criterion estimated is the LC50 (Median Lethal Concentration) a statically derived concentration of the test item in water which can be expected to cause death in 50% of the animals.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Fenspiride
EC Number:
225-751-3
EC Name:
Fenspiride
Cas Number:
5053-06-5
Molecular formula:
C15H20N2O2
IUPAC Name:
8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
batch OP 030/04/GP1

Test organisms

Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
96 h

Test conditions

Hardness:
between 10 to 250mg/L as CaCO3
Test temperature:
13°C to 17°C
pH:
between 6.0 and 8.5
no necessary adjustement
Dissolved oxygen:
dissolved oxygen concentrations < 60% of the air saturation value
Nominal and measured concentrations:
0 to 100mg/L
Reference substance (positive control):
yes

Results and discussion

Effect concentrations
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 10 - < 100 mg/L
Conc. based on:
test mat. (total fraction)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The highest concentration without clinical effect and without mortality at 96h was 10mg/L.
The lowest concentration with mortality of 100% at 96h was 100mg/L.
The LC50 at 24h, 48h, 72h and 96h were between 10 to 100mg/L