Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-640-0 | CAS number: 7665-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Excerpt from US EPA report. Expert opinion. Data extracted from Revised Robust Summaries.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Butyl glycidyl ether, CAS 2426-08-6, Purity: 99.8% Measured
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- Time points for the preliminary test were time zero and Day 5. Times for the definitive tests were chosen so that at least six time points were sampled at 20-70% of total hydrolysis.
- Positive controls:
- not specified
- Transformation products:
- no
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- ca. 0.3 h
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 20.3 d
- Other kinetic parameters:
- The rate of hydrolysis was extrapolated to 25°C for pH 4.0 and 7.0 using the Arrhenius equation: k(obs) = Ae-(Ea/RT) or ln k(obs) = Ln A -Ea/RT
- Details on results:
- t1/2 pH 4: ca. 1 hour(s) at 10 ºC
The rate of hydrolysis was determined to be:
19.64 l/s x l0e5 for pH 4.0 (10ºC),
68.75 l/s x l0e5 for pH 4.0 (20ºC),
0.04 l/s x l0e5 for pH 7.0 (20°C)
0.26 l/s x l0e5 for pH 7.0 (40°C)
There was not a determined rate of hydrolysis for pH 9.0 (50°C) since hydrolysis was less than 10%.
The extrapolated rates of hydrolysis for:
12.44 l/s x l0e5 for pH 4.0 (25°C)
6.26 l/s x l0e5 for pH 7.0 (25°C)
Therefore, the test substance, n-Butyl glycidyl ether, CAS RN 2426-08-6, underwent rapid hydrolysis at pH 4.0. The rate of hydrolysis slowed down as the pH was increased. - Validity criteria fulfilled:
- not specified
- Remarks:
- Excerpt from US EPA report. Data extracted from Revised Robust Summaries.
- Conclusions:
- The test substance n-Butyl glycidyl ether (CAS No. 2426-08-6), underwent rapid hydrolysis at pH 4.0. The rate of hydrolysis slowed down as the pH was increased.
- Executive summary:
In the course of a OECD 111 study butyl glycidyl ether has been assessed to be readily and moderately hydrolysable at pH 4 and 7 (with half-times of 0.3 hours and 20.3 days, respectively). At pH 9 and 50 °C no remarkable hydrolysis rate has been determined, as the hydrolysis rate was less than 10 % under these conditions.
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Expert opinion. Data extracted from revised robust summaries.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Details on sampling:
- not specified
- Details on test conditions:
- not specified
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 2.83 d
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 3.66 d
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- 2.22 d
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The substance is readily hydrolysable.
- Executive summary:
In the course of a OECD 111 study glycidyl methacrylate has been assessed to be readily hydrolysable (with T1/2 = 2.83, 3.66 and 2.22 day at pH 4,7,and 9, respectively).
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The source compound n-butyl glycidyl ether (EC 219-376-4, CAS 2426-08-6) is considered a suitable read across partner for tert-butyl glycidyl ether (EC 231-640-0, CAS 7665-72-7). Both substances are structural isomers regarding the alkyl chain structure.
Both ethers have similar physico-chemical properties. Both are highly water soluble (20 g/L vs 90 g/L), exhibit similar log Kow values (0.63 vs 0.97), similar boiling points (169 °C vs 152 °C) and vapour pressure (3.5 hPA vs 6.26 hPa) compared to tert-butyl glycidyl ether.
Under the conditions of the hydrolysis test, both substances will react with water: in the course of a ring opening, a vicinal diol will be formed as the final product (the ether group will remain intact under the conditions of this test). Since both substances have alkyl chain groups with identical molecular weight (n-butyl and tert-butyl), it can reasonably be inferred that the ring opening in tBGE will take place within the same magnitude as that of n-BGE. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- Time points for the preliminary test were time zero and Day 5. Times for the definitive tests were chosen so that at least six time points were sampled at 20-70% of total hydrolysis.
- Positive controls:
- not specified
- Preliminary study:
- A preliminary experiment was used to determine the approximate rate of hydrolysis of the test substance and the course of further testing. This test was performed at all three pH levels (4.0, 7.0 and 9.0) at 50 +/- 0.1 ºC for five days and the outcomes determined further testing. A sample of test substance was weighed into an autoclaved vial of sterile buffer solution (pH 4.0, 7.0 and 9.0) and then dispersed by syringe to appropriately labeled, autoclaved containers using aseptic technique. The containers were sealed, covered with foil, purged with nitrogen and placed in the appropriate constant temperature bath until retrieved for sampling. The quantity of containers was sufficient to allow for removal of one container at each time point.
- Transformation products:
- not specified
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- ca. 0.3 h
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 20.3 d
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 21 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Other kinetic parameters:
- The rate of hydrolysis was extrapolated to 25°C for pH 4.0 and 7.0 using the Arrhenius equation: k(obs) = Ae-(Ea/RT) or ln k(obs) = Ln A -Ea/RT
- Details on results:
- t1/2 pH 4: ca. 1 hour(s) at 10 ºC
The rate of hydrolysis was determined to be:
19.64 l/s x l0e5 for pH 4.0 (10ºC),
68.75 l/s x l0e5 for pH 4.0 (20ºC),
0.04 l/s x l0e5 for pH 7.0 (20°C)
0.26 l/s x l0e5 for pH 7.0 (40°C)
There was not a determined rate of hydrolysis for pH 9.0 (50°C) since hydrolysis was less than 10%.
The extrapolated rates of hydrolysis for:
12.44 1s x l0e5 for pH 4.0 (25°C)
6.26 l/s x l0e5 for pH 7.0 (25°C)
Therefore, the test substance, n-Butyl glycidyl ether, CAS RN 2426-08-6, underwent rapid hydrolysis at pH 4.0. The rate of hydrolysis slowed down as the pH was increased. - Validity criteria fulfilled:
- not specified
- Conclusions:
- The test substance, n-Butyl glycidyl ether (CAS No. 2426-08-6), underwent rapid hydrolysis at pH 4.0. The rate of hydrolysis slowed down as the pH was increased.
- Executive summary:
In the course of a OECD 111 study butyl glycidyl ether has been assessed to be readily and moderately hydrolysable at pH 4 and 7 (with half-times of 0.3 hours and 20.3 days, respectively). At pH 9 and 50 °C no remarkable hydrolysis rate has been determined, as the hydrolysis rate was less than 10 % under these conditions.
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- There is no study available elucidating the hydrolytic stability of the target substance tert-butyl glycidyl ether. Therefore, a hydrolysis study conducted with glycidyl methacrylate was used in a read-across approach.
This read-across is based on the hypothesis that source and target substances have similar physico-chemical properties because:
- of structural similarity of the target and the source substances (the presence of the identical functional group (2,3-epoxypropyl ether)
- similarity in physico-chemical profile of the source and target substances (MW, water solubility, partitioning behaviour (log Kow value)). - Reason / purpose for cross-reference:
- read-across source
- Transformation products:
- not specified
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 2.83 d
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 3.66 d
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- 2.22 d
- Conclusions:
- The substance is readily hydrolysable.
- Executive summary:
In the course of a OECD 111 study glycidyl methacrylate has been assessed to be readily hydrolysable (with T1/2 = 2.83, 3.66 and 2.22 day at pH 4,7,and 9, respectively).
Referenceopen allclose all
Description of key information
There is no study available elucidating the hydrolytic stability of the target substance tert-butyl glycidyl ether. Therefore, for the determination of the hydrolysis rate the substances 2,3-epoxypropyl methacrylate (EC No. 203-441-9) and n-butyl glycidyl ether (EC No. 219-376-4) are considered as appropriate read-across partners.
This read-across is based on the hypothesis that source and target substances have similar physico-chemical properties, triggered mainly due to similar physico-chemical properties (MW, water solubility, partitioning behaviour (log Kow value) and the presence of the same reactive functional group (2,3-epoxypropyl ether group).
Since n-BGE and tBGE are substances with the same molecular weight (which differentiate only in the structure of the butyl-group), the determined hydrolysis rate for nBGE will therefore be used as a comparative value for the determination of the same value for tBGE.
Consequently, the half-life of tBGE is estimated to 20.3 d (at pH 7 and 20°C).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 20.3 d
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.