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EC number: 270-365-0 | CAS number: 68425-65-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 to 28 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The acute toxicity to Daphnia study was undertaken as a bridging study to demonstrate equivalence between the Target substance (XP 473) and the Source substance (aluminum, benzoate C16-18-fatty acids complexes; CAS 94166-87-7) for the read-across of other data. A full discussion of read-across and supporting data is given in the attached justification in the endpoint for acute toxicity to fish.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- April 13, 2004.
- Deviations:
- yes
- Remarks:
- Mixing and settling periods for sample preparation selected by study monitor.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Oxo(propan-2-olato)aluminium
- EC Number:
- 270-365-0
- EC Name:
- Oxo(propan-2-olato)aluminium
- Cas Number:
- 68425-65-0
- Molecular formula:
- C3 H7 Al O2
- IUPAC Name:
- oxo(propan-2-olato)aluminium
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration of XP 473 was determined by measuring the concentration of total aluminum in all control and test substance treatment solutions at 0 and 48 hours. The 0-hour samples were collected from the parent solutions and the 48-hour samples were collected after combining replicate test solutions by treatment.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test solutions prepared by water-accommodated fraction (WAF), prepared by adding test substance to water to achieve 100 mg/L loading rate. Solution stirred for 72 h at room temperature while being shielded from light. Mixing was followed by 24 h settling period. Then the solution was filtered first through glass wool, and then through a 0.2 µm filter. The filtered solution was used as the 100 mg/L nominal loading rate test solution, and also for dilution to lower concentrations. The control solution was prepared in a similar way, but with dilution water only.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna neonates (<24-hours old) were obtained from an in house daphnid culture. All daphnids were cultured in a temperature-controlled area at approximately 20°C. During the culture period, the daphnids were fed a suspension of the algal species Raphidocelis subcapitata (formerly Selenastrum capricornutum) at least once a day supplemented by an artificial diet consisting of a wheat grass, salmon starter, and yeast suspension (YCT). Less than 24 hours old neonates for the definitive test were collected from in-house culture containing adults that were approximately 27 days old. The adults were considered acceptable with no signs of stress, disease or physical damage. Since the culturing and testing environmental parameters were equivalent (i.e., temperature, dilution water, and lighting), no acclimation period was necessary. Test daphnids were not fed during the test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Remarks:
- The dilution water used for the definitive test was natural surface water collected on-site at the testing facility, and tested to verify it was free of contaminants that might interfere with test results.
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 180 mg CaCO3/L
- Test temperature:
- 20 °C
- pH:
- 8.5 to 8.6
- Dissolved oxygen:
- 5.3 to 8.9 mg/L (62 to 105% saturation)
- Conductivity:
- 692 μS/cm
- Nominal and measured concentrations:
- Nominal, based on water-accommodated fractions (WAF): 0 (control), 6.3, 13, 25, 50, and 100 mg total product per litre.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 79.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- The 24-hour EC50 value was estimated to be >100 mg TP/L, the highest concentration tested. The 48-hour EC50 value was estimated to be 79.4 mg TP/L, with 95% confidence limits of 70.4 and 89.4 mg TP/L. The 48 hour NOEC was 50 mg TP/L, based on the nominal XP 473 loading rate concentrations and the lack of statistically significant effects at this, and all lower test substance concentrations.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour EC50 value was estimated to be 79.4 mg/L (WAF).
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