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EC number: 272-323-7 | CAS number: 68804-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 august to 05 september 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Study performed according to international guidelines without any deviation but not under GLP.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,7,7-trimethylbicyclo[4.1.0]heptane-2-carbaldehyde
- EC Number:
- 272-323-7
- EC Name:
- 3,7,7-trimethylbicyclo[4.1.0]heptane-2-carbaldehyde
- Cas Number:
- 68804-33-1
- Molecular formula:
- C11H18O
- IUPAC Name:
- 3,7,7-trimethylbicyclo[4.1.0]heptane-2-carbaldehyde
- Test material form:
- liquid
- Details on test material:
- No confidential details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: IOPS (strain OFA SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: Elevage IFFA CREDO (69210 L'Arbresle, France)
Number and sex: 5 males treated and 5 males control
Housing: 5 animals per cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME ADMINISTERED: 2 g/kg
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- 5 males at 2 g/kg
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing
Clinical signs and mortality: Animals were observed for any behavioural or toxic effects at day -1, 0, 3 7 and 14 after administration of the item..
Bodyweight was recorded on Day-1, at day 0 after administration, and at day 3, 7 and 14
- Necropsy of survivors performed: Yes; On Day 15, animals were anaesthetised before a macroscopic examination. - Statistics:
- None
Results and discussion
- Preliminary study:
- Not Applicable
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Mortality:
- No death of animals was observed during 14 days of experimentation.
No organic or tissue lesion was observed during the autopsy. - Clinical signs:
- Not applicable
- Body weight:
- Evolution of body weight of rats treated was comparable to control.
- Gross pathology:
- Not applicable
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 for 3,7,7-TRIMETHYLBICYCLO[4.1.0]HEPTANE-2-CARBOXALDEHYDE is higher than 2000 mg/kg.
- Executive summary:
In an acute oral toxicity study (limit test) performed according to OECD Guideline 401, 5 male rats were given a single oral (gavage) dose of 3,7,7-TRIMETHYLBICYCLO[4.1.0]HEPTANE-2-CARBOXALDEHYDE at 2 g/kg. Animals were then observed for mortality, clinical signs and bodyweights for 14 days and were all sacrificed for macroscopic examination.
No death of animals was observed during 14 days of experimentation. No organic or tissue lesion was observed during the autopsy.
The oral LD50 for 3,7,7-TRIMETHYLBICYCLO[4.1.0]HEPTANE-2-CARBOXALDEHYDE is higher than 2000 mg/kg. Therefore, the substance is not classified according to CLP regulation (EU) No.1272/2008.
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