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EC number: 232-369-0 | CAS number: 8008-63-7 Extractives and their physically modified derivatives such as proteins, lipids, carbohydrates, nucleic acids, inorganic ions, etc. obtained from mammalian bile.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2018-05-23 to 2019-02-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Decomp. temp.:
- ca. 180 °C
- Conclusions:
- The test item decomposes before melting.
- Executive summary:
A study was conducted according to OECD TG 102, Regulation (EC) No 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the melting point of the test item using differential scanning calorimetry DSC. The test item was weighed into an aluminium crucible. One test with about 6 mg of the test item was performed. As reference crucible, an empty aluminium crucible was used. The substance is a solid at ambient conditions. Therefore, the test was started at ambient temperature. The temperature was increased up to 500 °C at a constant heating rate of 10 K/min under air. In the temperature range of 80 – 150 °C, a first endothermic effect was observed. Between 310 – 410 °C a second endothermic effect could be detected. For a verification of the DSC measurement the capillary method was performed. Three capillaries were prepared and measured. In the first one foaming formation at ca. 140 °C was observed. In the second at ca. 160 °C and in the third the darkened test item flowed back to the bottom of the capillary at ca. 180 °C. Combining the results of the DSC measurement and the capillary method, none of the endothermic effects can be assigned to the melting of the test item. The test item started to decompose at ca. 180 °C before melting.
Reference
In the temperature range of 80 – 150 °C, a first endothermic effect was observed. Between 310 – 410 °C a second endothermic effect could be detected.
Table 1: Results of the DSC-measurements
No. |
Sample weight / mg |
Onset of Effect / °C |
Range of effect / °C |
Weight loss / mg |
Atmospheric pressure / hPa |
PN15782 |
6.34 |
78.8 |
80 – 150 (endo) |
4.30 |
1001.9 |
For a verification of the DSC measurement the capillary method was performed. In two of three capillaries the light brown test item started foaming and ascending in the capillary at approx. 140 °C. In the third capillary the test item showed this behavior at approx. 160 °C. In one of the capillaries, the darkened test item flowed back to the bottom of the capillary at approx. 180 °C.
Combining the results of the DSC measurements and of the capillary method, none of the endothermic effects can be assigned to the melting of the test item.
The test item started to decompose at approx. 180 °C.
Description of key information
The test item decomposes at ca. 180 °C before melting.
Key value for chemical safety assessment
Additional information
A study was conducted according to OECD TG 102, Regulation (EC) No 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the melting point of the test item using differential scanning calorimetry DSC. The test item was weighed into an aluminium crucible. One test with about 6 mg of the test item was performed. As reference crucible, an empty aluminium crucible was used. The substance is a solid at ambient conditions. Therefore, the test was started at ambient temperature. The temperature was increased up to 500 °C at a constant heating rate of 10 K/min under air. In the temperature range of 80 – 150 °C, a first endothermic effect was observed. Between 310 – 410 °C a second endothermic effect could be detected. For a verification of the DSC measurement the capillary method was performed. Three capillaries were prepared and measured. In the first one foaming formation at ca. 140 °C was observed. In the second at ca. 160 °C and in the third the darkened test item flowed back to the bottom of the capillary at ca. 180 °C. Combining the results of the DSC measurement and the capillary method, none of the endothermic effects can be assigned to the melting of the test item. The test item started to decompose at ca. 180 °C before melting.
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