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Diss Factsheets
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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
- Study type:
- direct photolysis
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-2 (Photodegradation Studies in Water)
- Deviations:
- yes
- Remarks:
- This study was conducted in natural sunlight. Deficiencies concern the extrapolation of the photolysis kinetic results to 40-65 degrees North latitude.
- GLP compliance:
- yes
Test material
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 724.0209
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: 97.2 %
- Specific activity: 31.61 mCi/g
- Locations of the label: 14C label was in the 4 and 5 carbons
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Not described
- Stability under test conditions: The compound is hydrolytically stable at pH 7 (25°C; DT50 >60 days)
- Solubility and stability of the test substance in the solvent/vehicle: Water solubility is greater than 1000 ppm in distilled water
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dilution in sterile buffer
- Preliminary purification step (if any): No
- Final dilution of a dissolved solid, stock liquid or gel: 10 ppm 14C-CMIT
FORM AS APPLIED IN THE TEST (if different from that of starting material)
Liquid
Study design
- Radiolabelling:
- yes
- Analytical method:
- gas chromatography
- high-performance liquid chromatography
- mass spectrometry
- other: liquid scintillation counter, thin layer chromatography
- Details on sampling:
- - Sampling intervals for the parent/transformation products: Days 0, 1, 4, 6, 8, and 15
- Sampling method: A sample was transferred from its photolysis tube into a sample vial, the photolysis tube rinsed with 1 mL of acetonitrile and the rinse added to the test solution.
- Sampling methods for the volatile compounds, if any: NaOH and ethylene glycol trap
- Sampling intervals/times for pH measurements: Prior to the study initiation and at sampling intervals (days 0, 1, 4, 6, 8, and 15)
- Sampling intervals/times for sterility check: Not described
- Sample storage conditions before analysis: All samples were radioassayed at the time of sampling and then stored at less than 0°C
- Other observation, if any (e.g.: precipitation, color change etc.): No - Buffers:
- - pH: 7
- Type and final molarity of buffer: phosphate buffer 0.01 M
- Composition of buffer: 0.3471 g of Na2HPO4•7H2O and 0.1526 g of KH2PO4 with 250 mL of water - Light source:
- sunlight
- Details on light source:
- - Location: Richmond, CA, USA
- Latitude: 37.45N
- Longitude: 122.26 W
- Hours of daylight: 11 to 11.5 h
- Time of year/month: From 20 February 1992 to 6 March 1992
- Light intensity: Average of 5.99 ± 1.81 W•min/cm2 (ranged from 1.50-7.98 W•min/cm2)
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test apparatus/vessels: quartz photolysis tubes which had an 11 mm inside diameter and were 205 mm in height
- Sterilisation method: Autoclave
- Measures to saturate with oxygen: Air pumped with a vacuum pump
- Details of traps for volatile, if any: 10 % NaOH and ethylene glycol traps
- Indication of test material adsorbing to the walls of test apparatus: No
TEST MEDIUM
- Volume used/treatment: 10 mL
- Kind and purity of water: Phosphate buffer
- Preparation of test medium: The phosphate buffer was prepared by adding 0.3471 g of Na2HPO4•7H2O and 0.1526 g of KH2PO4 with 250 mL of water to a 500 mL volumetric flask
- Renewal of test solution: No
REPLICATION
- No. of replicates (dark): 2
- No. of replicates (irradiated): 2
Duration of test at given test condition
- Duration:
- 15 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 10 mg/L
- Reference substance:
- no
- Dark controls:
- yes
Results and discussion
% Degradationopen allclose all
- % Degr.:
- 79.6
- Sampling time:
- 15 d
- Test condition:
- Natural sunlight
- % Degr.:
- 62.4
- Sampling time:
- 8 d
- Test condition:
- Natural sunlight
- % Degr.:
- 49.5
- Sampling time:
- 6 d
- Test condition:
- Natural sunlight
- % Degr.:
- 32.8
- Sampling time:
- 4 d
- Test condition:
- Natural sunlight
- % Degr.:
- 12.2
- Sampling time:
- 1 d
- Test condition:
- Natural sunlight
- % Degr.:
- 8.5
- Sampling time:
- 0 d
- Test condition:
- Natural sunlight
- % Degr.:
- < 5
- Sampling time:
- 15 d
- Test condition:
- Dark
Dissipation half-life of parent compound
- Key result
- DT50:
- 6.6 d
- Test condition:
- Natural sunlight
- Predicted environmental photolytic half-life:
- Not calculated since natural sunlight was used as the light source
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- Details on results:
- HALF-LIFE
6.6 days
TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
MAJOR TRANSFORMATION PRODUCTS (distinguish between dark and irradiated samples)
- Range of maximum concentrations in % of the applied amount at end of study period: 30.4% (Degradate #1) and 37.6% (Degradate #2)
TOTAL UNIDENTIFIED RADIOACTIVITY (RANGE) OF APPLIED AMOUNT (distinguish between dark and irradiated samples): Irradiated samples, 4.8 ± 3.1 %; Dark controls, 2.5 ± 3.1 %; and Total, 3.6 ± 3.3 %.
MINERALISATION (distinguish between dark and irradiated samples)
- % of applied radioactivity present as CO2 at end of study: 0.6% volatiles at the end of the 15 day sunlight exposure, negligible in dark conditions
VOLATILIZATION (distinguish between dark and irradiated samples)
- % of the applied radioactivity present as volatile organics at end of study: 0.6% volatiles at the end of the 15 day sunlight exposure, negligible in dark conditions
TRANSFORMATION PATHWAY
- Description of biotransformation pathway: The major degradative pathway involves cleavage of the isothiazolone ring
- Figure attached: No
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- This study fulfils the requirement for determining the effect of aqueous photolysis on the fate of CMIT in the environment. The half-life in natural sunlight is 6.6 days (rate constant, 0.105 day-1). The major photodegradation products are 5-chloro-3-methyl-4-thiazolin-3-one and N-methyl malonamic acid. The major degradative pathway involves cleavage of the isothiazolone ring.
- Executive summary:
Sterile pH 7 phosphate buffer was prepared and dosed at nominal 10 ppm14C CMIT. Ten mL were aseptically transferred to quartz photolysis tubes and placed on a roof top in Richmond, CA, USA in a water bath maintained at 24.8 ± 0.5°C for 15 days. Air was passed through the tubes and evolved volatiles trapped using NaOH and ethylene glycol. Replicate tubes were removed at Days 0, 1, 4, 6, 8, and 15 and analyzed by radioassay and HPLC. Test guidelines wereU.S. Environmental Protection Agency, 40 CFR § 158, Environmental Fate Assessment Guidelines, Subdivision N, Chemistry, Environmental Fate 161-2. No actinometer study was performed since this was not a requirement of the guidelines at the time the study was performed.
This study fulfils the requirement for determining the effect of aqueous photolysis on the fate of CMIT in the environment. The half-life in natural sunlight is 6.6 days (rate constant, 0.105 day-1). The major photodegradation products are 5-chloro-3-methyl-4-thiazolin-3-one and N-methyl malonamic acid. The major degradative pathway involves cleavage of the isothiazolone ring.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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