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EC number: 618-690-2 | CAS number: 90982-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- 0.5 and 5 ppm solutions (pH 5, 7, and 9) of the radiolabeled test substance, with the radiolabel located in the phenyl and pyrimidine moiety of the test substance, were incubated in water for 30 days. Aliquots were removed after 0, 1, 3, 9, 14, 21, and 30 days of incubation. The pH of each aliquot was adjusted to between 3 and 4 with dilute acetic acid. Each acidified aliquot was then extracted three times with 20-mL portions of methylene chloride. The combined methylene chloride extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated to 5 mL under a stream of nitrogen. The extracted, aqueous phase was neutralized with dilute ammonium hydroxide and concentrated to 5 mL under a stream of nitrogen. The radioactivity remaining in the extracted aqueous phase, the combined methylene chloride phase, and the concentrates was measured by liquid scintillation counting (LSC).
- GLP compliance:
- no
Test material
- Reference substance name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- EC Number:
- 618-690-2
- Cas Number:
- 90982-32-4
- Molecular formula:
- C15H15ClN4O6S
- IUPAC Name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- Test material form:
- solid
- Remarks:
- White
- Details on test material:
- 95 to >99% purity
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- The radiolabel was located in the phenyl and pyrimidine moiety of the test substance
Study design
- Analytical monitoring:
- no
Duration of testopen allclose all
- Duration:
- 30 d
- pH:
- 5
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.5 other: ppm
- Duration:
- 30 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.5 other: ppm
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.5 other: ppm
- Duration:
- 30 d
- pH:
- 5
- Temp.:
- 25 °C
- Initial conc. measured:
- 5 other: ppm
- Duration:
- 30 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 5 other: ppm
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 5 other: ppm
- Number of replicates:
- 1
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 611-882-7]
- CAS number:
- 59777-72-9
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 611-506-1]
- CAS number:
- 5734-64-5
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- At pH 5, the major hydrolysis products were 2-(aminosulfonyl)benzoic acid, ethyl ester (63-65% at day 30) and 4-chloro-6-methoxy-2-pyrimidinamine (71-78% at day 30). At pH 7 and pH 9, 6% or less of the original radioactivity was identified as 2-(aminosulfonyl)benzoic acid, ethyl ester, and 11% or less of the original radioactivity was identified as 4-chloro-6-methoxy-2-pyrimidinamine.
- Executive summary:
0.5 and 5 ppm solutions (pH 5, 7, and 9) of the radiolabeled test substance, with the radiolabel located in the phenyl and pyrimidine moiety of the test substance, were incubated in water for 30 days. Aliquots were removed after 0, 1, 3, 9, 14, 21, and 30 days of incubation. The pH of each aliquot was adjusted to between 3 and 4 with dilute acetic acid. Each acidified aliquot was then extracted three times with 20-mL portions of methylene chloride. The combined methylene chloride extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated to 5 mL under a stream of nitrogen. The extracted, aqueous phase was neutralized with dilute ammonium hydroxide and concentrated to 5 mL under a stream of nitrogen. The radioactivity remaining in the extracted aqueous phase, the combined methylene chloride phase, and the concentrates was measured by liquid scintillation counting (LSC).
At pH 5 in the dark at 25°C, the radiolabeled test substance hydrolyzed with a first half-life of about 17 and 25 days, respectively for the pyrimidine and phenyl labeled moieties; the half-life was independent of initial concentration. The major hydrolysis products were 2-(aminosulfonyl)benzoic acid, ethyl ester (63 - 65%) and 4-chloro-6-methoxy-2-pyrimidinamine (71 - 78%). Less than 10% of the original radioactivity was found as polar materials. The nature of these polar materials was not investigated.
The radiolabeled test substance was stable for 30 days at pH 7 and pH 9 at 25°C. 6% or less of the original radioactivity was identified as 2-(aminosulfonyl)benzoic acid, ethyl ester, and 11% or less of the original radioactivity was identified as 4-chloro-6-methoxy-2-pyrimidinamine. Polar materials constituted less than 10% of the original radioactivity during the exposure period.
Total radiolabel recoveries at the end of the 30-day exposure period ranged from 96 to 109% of the original, applied radioactivity, indicating no loss of volatile, radiolabeled compounds.
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