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EC number: 229-765-0 | CAS number: 6713-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 25, 2017 to September 22, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- 1992
- Deviations:
- yes
- Remarks:
- No valid microbial counts could be reported for aged inoculum due to high counts on the control plates.
- Principles of method if other than guideline:
- No valid microbial counts could be reported for aged inoculum due to high counts on the control plates. However, as the soluble reference material (sodium benzoate) degraded by more than 60% in the first 14 days, the test inoculum likely contained a satisfactory population of viable bacteria and this deviation is believed to have had no impact.
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Date of collection: July 05, 2017; Collection point: Stromness Treatment Works, Bu Point; Grid reference: HY 27332 09332; Latitude: 58.964975, Longitude: -3.2653023
- Water filtered: Yes
- Type and size of filter used, if any: Inoculum filtered through 1 μm Whatman filter prior to use in the test
- Volume of inoculum added: 1.3 mL/L
INOCULUM PROPERTIES
- pH: 7.07
- Temperature: 21.7 ºC
- Conductivity: 2.3 µS/cm
- Dissolved oxygen: 4.61 mg O2/l - Duration of test (contact time):
- 28 d
- Initial conc.:
- 2.737 mg/L
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium of deionised water. 1 L of medium contains 1 ml of stocks A, B, C, and D (Stock A = KH2PO4: 8.5, K2HPO4: 21.75, Na2HPO4.2HsO: 33.40, NH4Cl: O.5; Stock B = CaCl2: 27.50; Stock C = MgSO4.7H2O: 22.50; Stock D = FeCl3.6H2O: 0.25, EDTA, Di-sodium salt: 0.4)
- Solubilising agent: No, test material is soluble in water
- Test temperature: 22 ± 1 °C
- pH: Test water = 7.71 on collection day; Test inoculum = 7.07
- Aeration of dilution water: Yes, strongly for at least 20 minutes and then allowed to stand for a minimum of 20 hours at test temperature
- Continuous darkness: Yes
TEST SYSTEM
- Culturing apparatus: 270-276 ml glass BOD bottles
- Number of culture flasks/concentration: 3 replicate bottles per time-point for test material, oxygen black, reference material, and toxicity control. A minimum of 2 replicates per time-point is required for data processing
- Method used to create aerobic conditions: The solution of the 1- [(2-hydroxyethyl)thio]propan-2-ol in mineral medium was inoculated with microorganisms and kept in completely full, closed bottles in the dark at a constant temperature
- Measuring equipment: A luminescent dissolved oxygen meter (Hach HQ4Od) and probe (Hach LDO10101) were used to measure biodegradation
- Test performed in open system: No, glass BOD bottles were sealed
- Other: Microbial count using the spread plate method = a minimum of 1.0 x 10^1 to 1.0 x 10^3 colony forming units per ml of aged inoculum; Saturation value for dissolved oxygen at normal atmospheric pressure at 22 °C = minimum of ~9 mg/l; Soluble test material preparation = in stock solution (de-ionised water)
SAMPLING
- Sampling frequency: 7 day intervals (0, 7, 14, 21, and 28)
- Sampling method: A luminescent dissolved oxygen meter and probe (Hach HQ4Od and LDO10101) were used to measure luminescent dissolved oxygen
CONTROL AND BLANK SYSTEM
- Inoculum blank: Freshwater inoculum oxygen blank to provide a measure of background oxygen consumption in the test medium
- Toxicity control: A mixture of sodium benzoate (2 mg/l concentration) and test material (addition rate concentration) - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- (Sodium benzoate)
- Test performance:
- An initial test was conducted on June 07 - July 05, 2017 that met all validity criteria except for the blank oxygen consumption which exceeded the limit. The test was therefore repeated on July 12 - August 09, 2017 in accordance with the study plan and assessed for compliance, as previously, by the validity criteria outlined in OECD Guideline 301D (1992). The reference material, sodium benzoate, underwent > 60 % biodegradation in 14 days (76 %), the oxygen consumption blank (freshwater inoculum) had a reported dissolved oxygen depletion of = 1.5 mg/l in 28 days (1.28 mg/l), and the difference in replicate values was < 20 % at all time points. Residual oxygen in test bottles did not fall below 0.5 mg/l (> 0.5 mg/l), and in the inhibition test, the test and reference material in sum underwent > 25 % degradation in 14 days (29%). No valid microbial counts were reported for aged inoculum due to high counts on the control plates, however, this deviation was not thought to have had an impact as the soluble reference material degraded by > 60 % in the first 14 days, indicating that the test inoculum contained a satisfactory population of viable bacteria. No other deviation in the test was reported. All relevant validity criteria were met.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 0 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 15
- Sampling time:
- 21 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 15
- Sampling time:
- 28 d
- Details on results:
- Only two data points are required for data analysis. Replicates that reported a difference in biodegradation greater than 20 % were deemed abnormal and removed.
- Key result
- Parameter:
- ThOD
- Value:
- 1.995 other: mg O2/mg test mat.
- Results with reference substance:
- Sodium benzoate exhibted 99 % biodegradation after a 28 day period.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- After a 28 day period the percentage biodegradation for 1-[(2-hydroxyethyl)thio]propan-2-ol was reported as 15 % (based on O2 consumption). The registration substance does not fit the criteria of readily biodegradable.
- Executive summary:
The ready biodegradation of 1-[(2-hydroxyethyl)thio]propan-2-ol in an aerobic aqueous environment was determined in line with OECD Guideline 301 D - Ready Biodegradability: Closed Bottle Test. The study satisfied all validity criteria and a minor deviation, in which no valid microbial count could be obtained for aged inoculum, was not believed to have had an effect on the final result. After 28 days, percentage biodegradation of 1-[(2-hydroxyethyl)thio]propan-2-ol was report as 15 % (based on O2 consumption). This result did not achieve the pass removal level of 60 % of theoretical maximum within the 10 (or 14) day window. It is possible to conclude, therefore, that 1-[(2-hydroxyethyl)thio]propan-2-ol is not readily biodegradable under test conditions. As the degradation (%) of test material plus reference on day 14 equated to 29 %, it is further summarised that the substance is not inhibitory to bacteria (at the concentration used) as the study value is >25 %.
Reference
Control Test Data
Average control dissolved oxygen concentrations (mg O2/l):
Material | Day | ||||
0 | 7 | 14 | 21 | 28 | |
Oxygen consumption blank | 8.95 | 8.46 | 8.10 | 7.96 | 7.67 |
Sodium benzoate (2 mg/l concentration) | 8.95 | 6.11 | 5.95 | 5.20 | 5.18 |
Average control net oxygen consumption (BOD, mg O2/l):
Material | Day | |||
7 | 14 | 21 | 28 | |
Oxygen consumption blank | 0.50 | 0.85 | 0.99 | 1.28 |
Sodium benzoate | 2.35 | 2.50 | 3.26 | 3.28 |
Reference material percentage biodegradation:
Material | 100% BOD (mg/l) | Day | ||||
0 | 7 | 14 | 21 | 28 | ||
Sodium benzoate | 3.32 | 0 | 71 | 76 | 98 | 99 |
Blank oxygen demand:
Day | Mean dissolved oxygen (mg/l) | Mean BOD (mg/l) | BOD (%) |
0 | 8.95 | - | - |
7 | 8.46 | 0.50 | 6 |
14 | 8.10 | 0.85 | 9 |
21 | 7.96 | 0.99 | 11 |
28 | 7.67 | 1.28 | 14 |
1-[(2-hydroxyethyl)thio]propan-2-ol Analysed Test Data
Analysed test material percentage biodegradation for all replicates:
Material | 100% BOD (mg/I) | Day | ||||
0 | 7 | 14 | 21 | 28 | ||
Test material | 5.46 | 0.0 | 5.3 | 0.7 | 18.1 | 10.9 |
0.0 | 4.0 | 6.5 | 6.9 | 21.5 | ||
0.0 | 0.0 | 1.9 | 19.2 | 12.4 | ||
Difference between replicates | 0.0 | 5.3 | 5.8 | 12.3 | 10.6 | |
Test material + Sodium benzoate | 8.78 | 0.0 | 27.2 | 29.9 | 29.5 | 26.4 |
0.0 | 27.9 | 27.1 | - | 29.4 | ||
0.0 | 27.2 | 29.5 | 26.6 | 34.3 | ||
Difference between replicates | 0.0 | 0.7 | 2.8 | 2.9 | 7.9 |
Average analysed test material dissolved oxygen concentrations (mg O2/l):
Material | Day | ||||
0 | 7 | 14 | 21 | 28 | |
Test material | 8.95 | 8.29 | 7.94 | 7.16 | 6.86 |
Test material + Sodium benzoate | 8.95 | 6.05 | 5.58 | 5.51 | 5.04 |
Average analysed test material net oxygen consumption (BOD, mg O2/l):
Material | Day | |||
7 | 14 | 21 | 28 | |
Test material | 0.17 | 0.16 | 0.80 | 0.81 |
Test material + Sodium benzoate | 2.41 | 2.53 | 2.46 | 2.63 |
Analysed 1-[(2-hydroxyethyl)thio]propan-2-ol percentage biodegradation:
Material | 100% BOD (mg/l) | Day | ||||
0 | 7 | 14 | 21 | 28 | ||
Test material | 5.46 | 0 | 3 | 3 | 15 | 15 |
Test material + Sodium benzoate | 8.78 | 0 | 28 | 29 | 28 | 30 |
Assessment of potential inhibition of inoculum due to 1-[(2-hydroxyethyl)thio]propan-2-ol:
Day | Test material BOD (mg/l) | Sodium benzoate BOD (mg/l) | Sum of separate BODs (mg/l) | Inhibition control BOD (mg/l) | Percentage inhibition |
7 | 0.17 | 2.35 | 2.51 | 2.41 | 4 |
14 | 0.16 | 2.5 | 2.67 | 2.53 | 5 |
21 | 0.8 | 3.26 | 4.06 | 2.46 | 39 |
28 | 0.81 | 3.28 | 4.1 | 2.63 | 36 |
Description of key information
The ready biodegradation of 1-[(2-hydroxyethyl)thio]propan-2-ol in an aerobic aqueous environment was determined in line with OECD Guideline 301 D - Ready Biodegradability: Closed Bottle Test. The study satisfied all validity criteria and a minor deviation, in which no valid microbial count could be obtained for aged inoculum, was not believed to have had an affect on the final result. After 28 days, percentage biodegradation of 1-[(2-hydroxyethyl)thio]propan-2-ol was report as 15 % (based on O2 consumption). This result did not achieve the pass removal level of 60 % of theoretical maximum within the 10 (or 14) day window. It is possible to conclude, therefore, that 1-[(2-hydroxyethyl)thio]propan-2-ol is not readily biodegradable under test conditions. As the degradation (%) of test material plus reference on day 14 equated to 29 %, it is further summarised that the substance is not inhibitory to bacteria (at the concentration used) as the study value is >25 %.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
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