Registration Dossier
Registration Dossier
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EC number: 243-378-4 | CAS number: 19856-23-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from May 2nd to 4th, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- Adopted 23. March 2006
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Principles of method if other than guideline:
- Source of correction constants: E.D.Cater, Ch.2A, Physicochemical Measurements in Metal Research, Part 1, R.A. Rapp, Ed., John Wiley, New York, 1970
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Temp.:
- 135 °C
- Vapour pressure:
- 0.018 Pa
- Conclusions:
- Vapour pressure at 135 °C: 1.85* 10^-02 Pa
- Executive summary:
The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss).
Experiment 1-9 (nominal temperature 30-150 °C) showed no reproducible and relevant weight loss. No experiments could be evaluated as they showed no relevant and reproducible weight loss. Therefore, the highest vapour pressure, derived from all measurements, is stated as limit value.
Vapour pressure at 135 °C: 0.0185 Pa
Experiment 1-9 (nominal temperature 30-150 °C) showed no reproducible and relevant weight loss. No experiments could be evaluated as they showed no relevant and reproducible weight loss. Therefore, the highest vapour pressure, derived from all measurements, is stated as limit value.
Vapour pressure at 135 °C: 1.85* 10-02Pa
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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