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EC number: 806-827-0 | CAS number: 105351-42-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-12-13 to 2014-02-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: METI Guideline: Concentration Test on Chemical Substances in Fish
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Details on sampling:
- - Sampling intervals/frequency for test organisms: days 0, 5, 8, 14, 21, 28
- Sampling intervals/frequency for test medium samples: days 0, 5, 8, 14, 21, 28
- Fish: two fish per sampling homogenised, and extracted with acetonitril/n-hexane. Further analysis performed by GC. - Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- According to guideline
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): HCO-40
- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)): 10 mg/l
Dose 1: Test item: 0.015 mg/L ,
Dose 2: Test item: 0.0015 mg/L - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Cyprinus carpio
Lot: 131018c
Weight: 5.5 g
Length: 7.7 cm - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 28 d
- Total depuration duration:
- 0
- Hardness:
- 250 mg/L
- Test temperature:
- 25.0 ° +/- 0.4 °C
- pH:
- 7.0
- Dissolved oxygen:
- 7.0 mg/L
- Salinity:
- According to guideline
- Details on test conditions:
- After acclimatisation period, the fish (Cyprinus carpio) were transferred into the test media under flow through conditions. Exposure concentrations were analytically verified at days 5, 14, 21, and 28. The analytical values show that the nominal concentrations of 0.015 and 0.0015 mg/L were maintained during the experimental phase.
At days 5, 14, 21, 25 and 28 two fish each were removed from each test group. Body weight was determined. The fish were homogenised and extracted with acetonitrile and n-hexane and the extract was analysed.
Due to the low bioaccumulation potential, no depuration phase was required. - Nominal and measured concentrations:
- nominal concentration 0.015 mg/L:
analytically measured concentrations:
day 5: 0.0138 mg/L
day 8: 0.0167mg/L;
day 14: 0.0159 mg/L
day 21: 0.0129mg/L
day 28: 0.0152 mg/L
nominal concentration 0.0015 mg/L
analytically measured concentrations:
day 5: 0.00138 mg/L
day 7: 0.00152 mg/L;
day 14: 0.00149 mg/L
day 21: 0.00164 mg/L
day 28: 0.00159 mg/L - Details on estimation of bioconcentration:
- according to guideline
- Key result
- Type:
- BCF
- Value:
- 68 dimensionless
- Basis:
- normalised lipid fraction
- Time of plateau:
- 7 d
- Calculation basis:
- steady state
- Remarks on result:
- other: analytical concentration
- Remarks:
- Conc.in environment / dose:0.015 mg/L
- Key result
- Type:
- BCF
- Value:
- 16 dimensionless
- Basis:
- normalised lipid fraction
- Time of plateau:
- 14 d
- Calculation basis:
- steady state
- Remarks on result:
- other: analytical concentration
- Remarks:
- Conc.in environment / dose:0,0015 mg/L
- Details on kinetic parameters:
- steady state was reached within 7 (14) days
Due to the low uptake, no depuration phase was necessary - Metabolites:
- none
- Details on results:
- - Mortality of test organisms: no effects
- Behavioural abnormalities:no effects
- Observations on body length and weight:no effects
- Other biological observations: no effects
- Bound residues forming a plateau: no
- Mortality and/or behavioural abnormalities of control: no
- Loss of test substance during test period: no
- Results with vehicle control: no effects - Validity criteria fulfilled:
- yes
- Conclusions:
- The test material showed no relevant bioaccumulation at concentrations at or above the water solubility. The steady state BCF values were at 16 and 68 (mean 42). The test material showed no relevant bioaccumulation (BCF < 2000).
- Executive summary:
Purpose
The purpose of this study was to determine the bioconcentration potential of the test material in fish under flow-through conditions.
Study Design
The study was performed according to the OECD Guideline for Testing of Chemicals 305 (Bioconcentration: Flow-through Fish Test) adopted on June 14, 1996 using two test material concentrations for exposure to Cyprinus carpio. Two environmental concentrations of the test material of 0.015 and 0.0015 mg/L were used in this study. HCO-40 was used as vehicle at concentrations of 10 mg/L. The exposure was maintained during the couse of the study. The concentrations have been verified analytically using a GC method.
Results
No signs of toxicity were observed throughout the study. The analysis reveals steady state BCFs of 16 and 68. Due to the low bioaccumulation potential, no depuration phase was required.
Conclusion
The test material showed no relevant bioaccumulation at concentrations at or above the water solubility. The steady state BCF values were at 16 and 68 (mean 42). The test material showed no relevant bioaccumulation (BCF < 2000).
Reference
Description of key information
Date for this endpoint have been obtained in a experimental study performed according to GLP and the methods applied are fully compliant with OECD TG 305.
The BCFs are at 68 and 16 (mean 42) and thus < 2000.
Key value for chemical safety assessment
- BCF (aquatic species):
- 42 dimensionless
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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