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EC number: 205-450-3 | CAS number: 141-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD SIDS
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- no
- GLP compliance:
- yes
- Inoculum or test system:
- activated sludge, non-adapted
- Remarks:
- Japanese standard activated sludge
- Duration of test (contact time):
- ca. 28 d
- Key result
- Parameter:
- half-life in days (QSAR/QSPR)
- Value:
- ca. 1 850
- Sampling time:
- 28 d
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- >= 86 - <= 95
- Sampling time:
- 28 d
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Key result
- Parameter:
- % degradation (test mat. analysis)
- Remarks:
- GC analysis
- Value:
- >= 100
- Sampling time:
- 28 d
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Details on results:
- Readily biodegradable:
86-95% (BOD) in 28 days,
100% (GC) in 28 days - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- If released into water, this substance is readily biodegraded (MITI (I), corresponding to the OECD 301C: 86 - 95 % during 28 days based on BOD and 100 % based on GC analysis) (MITI, Japan, 1994b).
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- adopted in 1984
- Deviations:
- no
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Source of inoculum/activated sludge: obtained from municipal laboratory wastewater treatment plant (16 Mar 1987)
- Concentration of sludge: 30 mg/L (in test) - Duration of test (contact time):
- ca. 28 d
- Initial conc.:
- ca. 52 - 200 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Number of culture flasks/concentration: 100 mg/L: 3 replicats; 52/200 mg/L: two replicats
- pH: 6.8 - 7.8
CONTROL AND BLANK SYSTEM
- Toxicity control: yes - Reference substance:
- aniline
- Remarks:
- 100 mg/L
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- >= 90 - <= 100
- Sampling time:
- 28 d
- Details on results:
- - lag phase 3 day
- > Manometric Respirometry test60% degradation after 10 days
- biodegradation degree after 28 days: >90%
The test substance is readily biodegradable. - Results with reference substance:
- The toxicity control indicates that the test substance is not inhibitory to activated sludge microorganisms (> 90% degradation after 14 days)
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance reached a biodegradation of 90 - 100% in 28 days. The 10-day-window was passed. Therefore, the test substance is readily biodegradable according to OECD criteria.
- Executive summary:
The ready biodegradability of Bis(2-ethylhexyl) adipate was tested according to EU method C.4-D (manometric respirometry test equivalent to OECD 301F) under GLP conditions. Non-adapted municipal activated sludge was used as inoculum. The test substance was tested at concentrations between of 52 and 200 mg/L. The validity criteria are fulfilled. The pass level of 60% biodegradation was reached in less than 10 days. After 28 days a biodegradation of 90 – 100 % was observed. Therefore, the test substance is readily biodegradable according to OECD criteria.
Referenceopen allclose all
Type: aerobic [X]; anaerobic [ ]
Inoculum: adapted [ ]; non-adapted [X];
Concentration of 100 mg/l related to Test Substance [X]
the chemical:
Medium: water[ ];water-sediment[ ];soil [ ];sewage treatment [ ]
other [Japanese standard activated sludge]
Degradation: Degree of degradation after 28 days
89; 95; 86 % from BOD
100, 100 and 100 % from GC analysis
Results: Readily biodeg. [X]; Inherently biodeg. [ ]; under test condition no
biodegradation observed [ ]
Method: OECD Test Guideline 301 C
GLP: Yes [X] No [ ] ? [ ]
Test substance: Dibutyl adipate
Reference: MITI (1994b)
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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