Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-368-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological information
Specific investigations: other studies
Currently viewing:
Administrative data
Link to relevant study record(s)
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
Examine the agonistic activity of bisphenol-AF through ERα and ERβ. Also investigated was the effects of bisphenol-AF on ER-mediated target genes.
- Short description of test conditions:
HepG2 and HeLa cells were used to determine the agonistic activity of bisphenol-AF on ERα and ERβ via the luciferase reporter assay. Ishikawa cells stably expressing ERα were used to determine changes in endogenous ER target gene expression by bisphenol-AF.
- Parameters analysed / observed:
As described above. - GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- toxicity to reproduction / fertility
- Specific details on test material used for the study:
- RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: n/a
- Specific activity: n/a
- Locations of the label: n/a
- Expiration date of radiochemical substance: n/a
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not reported
- Stability under test conditions: not reported
- Solubility and stability of the test substance in the solvent/vehicle: test item disolved in ethanol
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not reported
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: test item dissolved in ethanol before being diluted in media
- Preliminary purification step (if any): n/a
- Final dilution of a dissolved solid, stock liquid or gel: test item dissolved in ethanol before being diluted in media- fianl concentration of solvent was 0.01 % v/v.
- Final preparation of a solid: n/a
FORM AS APPLIED IN THE TEST (if different from that of starting material): applied as a liquid
OTHER SPECIFICS: n/a - Species:
- other: Human cell lines
- Strain:
- other: Human cell lines
- Details on test animals or test system and environmental conditions:
- n/a (in vitro test)
- Details on analytical verification of doses or concentrations:
- n/a (see "any other information on materials and methods" section)
- Duration of treatment / exposure:
- n/a (see "any other information on materials and methods" section)
- Frequency of treatment:
- n/a (see "any other information on materials and methods" section)
- Post exposure period:
- n/a (see "any other information on materials and methods" section)
- No. of animals per sex per dose:
- n/a (see "any other information on materials and methods" section)
- Details on study design:
- n/a (see "any other information on materials and methods" section)
- Examinations:
- n/a (see "any other information on materials and methods" section)
- Positive control:
- n/a (see "any other information on materials and methods" section)