Registration Dossier
Registration Dossier
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EC number: 211-525-1 | CAS number: 658-79-7
Melting point / freezing point
Administrative data
Link to relevant study record(s)
Description of key information
- study according to OECD guideline 102, GLP, differential scanning calorimetry, a definitive melting point could not be determined under the test conditions, melting point approx. between 130 and 150 °C
- publication, non-guideline study, characterisation of different peptides by means of their physicochemical properties, melting point: 165 °C, decomposition: 174 -176 °C.
- publication, non-guideline study, synthesis of tripeptides and investigation of their stability during partial acid hydrolysis, first melting point: 164 °C, second melting point (i.e. decomposition): 294 °C.
- publication, non-guideline study, synthesis of tri- and tetrapeptides and the investigation and characterisation of their hydrolysis products after enzymatic hydrolysis, melting point before drying: 185 °C, after drying: 175 °C.
- publication, non-guideline study, characterisation and synthesis of di- and polypeptides, melting point: 265 °C.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 150 °C
Additional information
The above listed data provides evidence, that the ability to determine the melting point of N-glycyl-L-tyrosine is strongly dependent on the method used. Furthermore, the publications results indicate that the dipeptide decomposes in a range of 176 °C - 294 °C.
Most reliable data was provided by the determination of melting point of N-glycyl-L-tyrosine dihydrate in a study conducted according to OECD guideline 102. A preliminary thermogravimetric measurement, as well as a differential scanning calorimetry (DSC) was performed. During DSC, five steps were registered with maxima at 130 °C, 174 °C, 233 °C, 293 °C resp. 377 °C (380 °C in the second run). An accurate allocation of the single peaks to melting, possible emission of hydrate water or starting of decomposition was not possible under the conditions of the test. Since the information provided by the publications indicated decomposition,n and due to the first maximum detected between 130 and 150 °C, N-glycyl-L-tyrosine is considered to melt in this temperature range. Above a temperature of 175 °C the substance is assumed to decompose, which is in line with the published data.
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