Registration Dossier
Registration Dossier
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EC number: 201-317-9 | CAS number: 81-04-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study with limited information on test material, test animals, study design and clinical examination
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- limited test material, testing animal and study design information
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Naphthalene-1,5-disulphonic acid
- EC Number:
- 201-317-9
- EC Name:
- Naphthalene-1,5-disulphonic acid
- Cas Number:
- 81-04-9
- Molecular formula:
- C10H8O6S2
- IUPAC Name:
- naphthalene-1,5-disulfonic acid
- Test material form:
- solid: crystalline
- Details on test material:
- Unspecified test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 1500, 2000, 2200, 2500, 3100 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 420 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 200 - 2 710
Any other information on results incl. tables
Table 1: Mortality data
Dose [g/kg bw] |
Time to death [days] |
Mortality Number of dead/total animals |
1.5 |
- |
0/10 |
2.0 |
3 |
1/10 |
2.2 |
2-3 |
4/10 |
2.5 |
2 |
7/10 |
3.1 |
2 |
8/10 |
5.0 |
3-6 |
10/10 |
Applicant's summary and conclusion
- Executive summary:
Early study with acceptable scientific method. LD50: 2420 mg/kg (95th percentiles: 2200 -2710 mg/kg)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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