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EC number: 217-682-2 | CAS number: 1929-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Koc (adsorption) = 326 mL/g (average from 5 soils); Koc (desorption) = 1700 mL/g; Guideline 163-1, Peterson et al. (1987)
Koc (adsorption) = 564 mL/g (average of 8 soils), slurry method, Hanmaker (1974)
Key value for chemical safety assessment
- Koc at 20 °C:
- 461
Additional information
Available Data
In the key study (Peterson et al. 1987) the adsorption and desorption of the test material was investigated on five soils, at room temperature. The study was conducted under GLP conditions and in accordance with Guideline 163-1 and was assigned a reliability score of 1 in line with the criteria of Klimisch et al. (1997).
The adsorption and desorption of14C-labelled nitrapyrin were measured using the batch equilibrium method to determine the Kd and Koc values in five US-soils (o.c. content 0.3-5.65%, pH 5.4-7.1). An average adsorption Koc of 326 ml/g was determined for nitrapyrin and it can therefore be classified as having low to medium mobility in soil.
The desorption Koc values for the two intermediate soil metabolites, 2-chloro-6-(dichloromethyl)-pyridine (DCMP) and 6-chloro-2-picolinic acid (6 -CPA), were determined to be 860 mL/g and 190 mL/g, respectively.
Two references are included as supporting information. The first is in the form of a publication, reported by Goring (1961). It appears the study was conducted to sound scientific principles however minimal detail is provided on materials and methods; the study was therefore assigned a reliability score of 4 in line with the criteria of Klimisch et al. (1997).
During the study a 4 ppm solution of radioactive test material was prepared in water. Samples (0.5 g) of finely ground air-dry soils were placed in 10 mL test tubes and 2 mL of the chemical solution added to each soil sample. The tubes were stoppered with rubber stoppers covered with plastic film. The tubes were intermittently shaken for 30 minutes, centrifuged, and 0.25 mL samples of the supernatant placed on lens paper in planchets. The planchets were tightly covered with plastic film and equilibrated for 3 hours, after which counts were made. Check samples without soil were also run through the standardised procedure, and, from the results obtained, the sorption of the test material by the soils was calculated.
Under the conditions of the study there was no consistent relationship between sorption of the test material by the soil and the pH or clay content of the soil. There appeared to be a good relationship between sorption and % organic matter in the soil.
The ratios of the concentrations sorbed by the soils expressed on an organic-matter basis to the concentrations remaining in the soil solution were relatively constant. The test material partitions between the organic matter and the water, the coefficient being about 100 to 200. In conclusion, in moist soil the test material is highly sorbed by organic matter but not appreciably sorbed by the clay fraction of the soil.
The second reference included as supporting information is a publication as reported by Hanmaker (1974). It appears the study was conducted to sound scientific principles however minimal detail is provided on materials and methods. The study pre-dates GLP. The data are included as supporting information and have been assigned a reliability score of 4 in line with the criteria of Klimisch et al. (1997).
During the study the soil adsorption coefficient (Koc) of the test material was determined. No details about the analytical method/test solution preparation are explicitly stated. Adsorption was measured by the slurry method for 8 different soils in a 4:1 water-soil slurry mixture after 4 hours incubation and resulted in an average Koc value of 564 mL/g. Based on the results the test material would be classified as having low to medium mobility.
Organic Partition Coefficient (Koc)
The Kocs for the substance were taken from Hamaker (1974) and Petersen et al (1987). The Kocs and Freundlich coefficients (1/n) are given in the Table below.
Reported Koc values for the substance
Study |
Soil |
Kf/d |
1/n |
Koc |
Hamaker (1974) |
26 |
0.4 |
1 |
491 |
|
110 |
3.18 |
1 |
514 |
|
106 |
5.39 |
1 |
627 |
|
105 |
4.43 |
1 |
457 |
|
93 |
9.09 |
1 |
627 |
|
108 |
15.85 |
1 |
417 |
|
67 |
44 |
1 |
764 |
Petersen et al. (1987) |
M137 |
0.947 |
0.8935 |
287 |
|
M139 |
2.372 |
0.8138 |
377 |
|
M140 |
19.955 |
0.8991 |
352 |
|
M141 |
2.916 |
0.8674 |
360 |
|
M145 |
5.243 |
0.8325 |
254 |
|
Mean |
|
0.94 |
461 |
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