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Diss Factsheets
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EC number: 285-378-7 | CAS number: 85085-49-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha citrata, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- US national Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2018
- Reference Type:
- publication
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- D. L. J. Opdyke
- Year:
- 1 964
- Bibliographic source:
- Food and Cosmetics Toxicology
- Reference Type:
- publication
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- P. M. JENNER et. al.
- Year:
- 1 964
- Bibliographic source:
- Fd Cosmet. Toxicol
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2018
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- United Nations Environmental Programme (UNEP)
- Year:
- 2 002
- Bibliographic source:
- SIDS Initial Assessment Report For Linalool, United Nations Environmental Programme (UNEP)
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical
- Author:
- HPVIS
- Year:
- 2 018
- Bibliographic source:
- HPVIS,2018
- Reference Type:
- publication
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- D. Belsito et. al.
- Year:
- 2 008
- Bibliographic source:
- Food and Chemical Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- (3S)-3,7-dimethylocta-1,6-dien-3-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): (3S)-3,7-dimethylocta-1,6-dien-3-ol
- Common name: Linalool
- Molecular formula: C10H18O
- Molecular weight: 154.251 g/mol
- Smiles notation: C([C@@](C=C)(C)O)C\C=C(\C)C
- InChl: 1S/C10H18O/c1-5-10(4,11)8-6-7-9(2)3/h5,7,11H,1,6,8H2,2-4H3
- Substance type: Organic
- Physical State: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Age at study initiation: young adult rats
- Fasting period before study:18 hours
- Diet (e.g. ad libitum): the food was replaced in cages as soon as the animals received their
respective doses.
- Water (e.g. ad libitum):water was provided ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- 2790 mg/kg bw
- No. of animals per sex per dose:
- Total: 10 animals
2790 mg/kg bw: 5 males and 5 females - Control animals:
- not specified
- Details on study design:
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were maintained under close observation for toxic signs and time of death. Such observation was continued until animals appeared normal and showed weight gain. The usual observation period was 2 weeks.
- Other examinations performed: clinical signs - Statistics:
- LD50s were computed by the method of Litchfield & Wilcoxon (1949).
Results and discussion
- Preliminary study:
- no data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 790 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 440 - 3 180
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- Death occurred within 4-18 hours after treatment.
- Clinical signs:
- In clinical signs observations, Behavioral ataxia (soon after Treatment) was observed
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2790 mg/kg bw(95% C. I.: 2440-3180 mg/kg bw),when groups of 5 male and female Osborne-Mendel rats were treated with test chemical orally via gavage following 14 days of observation period.
- Executive summary:
Acute oral toxicity study was performed in groups of 5 male and female Osborne-Mendel rats using test chemical.LD50s were computed by the method of Litchfield & Wilcoxon (1949).50% mortality was observed at dose 2790 mg/kg bw.Death occurred within 4-18 hours after treatment. In clinical signs observations, Behavioral ataxia (soon after Treatment) was observed.Hence,LD50 value was considered to be2790 mg/kg bw(95% C. I.: 2440-3180 mg/kg bw),when groups of 5 male and female Osborne-Mendel rats were treated with test chemical orally via gavage following 14 days of observation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.