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EC number: 260-694-8 | CAS number: 57357-85-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- German BGA method (1991)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- [1S-(1α,2β,3α,5α)]-[2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]methylamine
- EC Number:
- 260-694-8
- EC Name:
- [1S-(1α,2β,3α,5α)]-[2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]methylamine
- Cas Number:
- 57357-85-4
- Molecular formula:
- C11H21N
- IUPAC Name:
- 1-[(1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl]methanamine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot No.of test material: 109 + 110/91
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adults
- Weight at study initiation: comparable
- Fasting period before study: ~16 h
- Housing: single-housed in stainless steel wire mesh cages, DK-III
- Diet: ad libitum, standardized animal laboratory diet
- Water: ad libitum, tab water
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4 and 44 g/100 mL
- Justification for choice of vehicle: The test substance was insoluble in water.
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg
- Doses:
- 200 (male and female animals), 2200 mg/kg (males only)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: General observation and mortalities was made twice each working day and once on weekends and on public holidays. Body weight determination was done shortly before administration (day 0), weekly thereafter and at the end of the study.
- Necropsy of survivors performed: Yes, at the last day of the observation period. Necropsy of all animals that died before as soon as possible.
- Other examinations performed: clinical signs, gross pathology
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male animals: 200 mg/kg: no deaths; 2200 mg/kg: 3/3
Female animals: 200 mg/kg: no deaths; 2200 mg/kg: not tested - Clinical signs:
- Signs of toxicity noted in the 2200 mg/kg bw dose group were: poor general state, dyspnoea, apathy, excitation, staggering, tremor, twitching, spastic gait, saltatory and flexion spasms, rolling convulsions, piloerection, and salivation.
The male animals of the 200 mg/kg bw dose group exhibited poor general state, dyspnoea, excitation, staggering, spastic gait, and piloerrection. They appeared normal 1 day after application.
The female animals of the 200 mg/kg bw dose group did not show any symptoms. - Body weight:
- Male animals (200 mg/kg) : 179 g at study start, 271 g after 13 days
Female animals (200 mg/kg): 169 g at study start, 216 g after 13 days - Gross pathology:
- Animals that died: diffuse reddening with blood extravasation into the lumen in the gastro-intestinal tract (2200 mg/kg: 3 males).
Sacrificed animals: no pathological findings noted (200 mg/kg; 3 males and 3 females)
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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