Registration Dossier
Registration Dossier
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EC number: 247-361-2 | CAS number: 25952-53-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Version / remarks:
- Method 6.1: 1996/Cor.1:1998
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- likely to be GLP but not specified in data available
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- No information is provided on how test solutions were prepared.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No details available on source and use of Daphnia magna. Assumed neonates used were less than 24 hours old in accordance with the followed guidance.
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20.7°C
- pH:
- 6.0
- Dissolved oxygen:
- 103 (% saturation)
- Salinity:
- < 1 ppt at 20°C
- Conductivity:
- 560 µS/cm at 20°C
- Nominal and measured concentrations:
- Nominal Concentrations of 0.1, 0.18, 0.32, 0.56 and 1.0 mg/L are detailed.
- Details on test conditions:
- No detailed information on experimental conditions available.
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.41 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Immobilisation results:
0.1 mg/L: No Daphnia immobilised.
0.18 mg/L: 5% of Daphnia immobilised.
0.32 mg/L: 30% of Daphnia immobilised.
0.56 mg/L: 70% of Daphnia immobilised.
1.0 mg/L: 100% of Daphnia immobilised. - Results with reference substance (positive control):
- Not specified
- Reported statistics and error estimates:
- 95% confidence limits of 0.39 to 0.49 (% vol/vol) calculated using Maximum likelihood
- Validity criteria fulfilled:
- not specified
- Conclusions:
- A semi-reliable study conducted in accordance with ISO guidance provides a 48 hr EC50 value of 0.41 mg/L to Daphnia magna.
Reference
Description of key information
A semi-reliable study conducted in accordance with ISO guidance provides a 48 hr EC50 value of 0.41 mg/L to Daphnia magna.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.41 mg/L
Additional information
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