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EC number: 279-349-8 | CAS number: 79916-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of 3,7-bis(diethylamino)phenoxazin-5-ium acetate (CAS no.79916 -07 -7) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor. Test substance undergoes 0.7666 % degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 3,7-bis(diethylamino) phenoxazin-5-ium acetate was estimated to be not readily biodegradable in water.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3,7-bis(diethylamino) phenoxazin-5-ium acetate (CAS no.79916 -07 -7). If released in to the environment,3.66% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate (CAS no.79916 -07 -7) in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate in sediment is estimated to be 541.66 days (13000 hrs). Based on this half-life value, it indicates that 3,7-bis(diethylamino)phenoxazin-5-ium acetate is persistent in sediment.
Biodegradation in soil:
The half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate (CAS no.79916 -07 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 58.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate in soil is estimated to be 120 days ( 2880 hrs). Based on this half-life value of 3,7-bis(diethylamino)phenoxazin-5-ium acetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
Additional information
Biodegradation in water:
Various predicted and experimental data for the target compound 3,7-bis(diethylamino)phenoxazin-5-ium acetate (79916-07-7) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 3,7-bis(diethylamino)phenoxazin-5-ium acetate was estimated. Biodegradability of 3,7-bis(diethylamino)phenoxazin-5-ium acetate (CAS no.79916 -07 -7) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor. Test substance undergoes 0.7666 % degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 3,7-bis(diethylamino) phenoxazin-5-ium acetate was estimated to be not readily biodegradable in water.
In a supporting weight of evidence study from peer reviewed journal (Fresenius Z. Anal. Chem, 1984) for the read across chemical (2465-27-2). Biodegradation study was conducted for evaluating the percentage biodegradability of test substance 4,4'-carbonimidoylbis(N,N-dimethylaniline) hydrochloride. (CAS no. 2465-27-2). Activated sludge was used as a test inoculum obtained from municipal sewage. Test substance of conc. 500 mg/l was prepared and diluted as needed. The COD measurement was performed by the potassium dichromate reflux method based on Japanese Industrial Standards. In the BOD measurement, a sample solution was taken into a container. Then JIS-BOD testing solutions, i.e. 3 ml of A solution and 1 ml of B, C, D solutions were added to the sample solution, respectively. Then 5 ml of the supernatant of the municipal sewage activated sludge was added to the sample solution and diluted to 300 ml with water. Immediately, the BOD-time curve was recorded at 20~ using an Ohkura OM-200I type coulometer. The TOC measurement was carried out by a Yanagimoto TOC-ILW.BOD5, COD, ThOD and TOC value of the test chemical was determined to be 0.038, 1.42, 2.50 and 0.32 g/g, respectively. The BOD5/TOC ratio of test chemical was determined to be 0.12 (i.e. ranges in between 0.08-0.89), indicating that the chemical is highly resistant to aerobic biodegradation. Thus, based on this value BOD5/TOC value, it can be concluded that the test chemical 4,4'-carbonimidoylbis(N,N-dimethylaniline) hydrochloride is not readily biodegradable in nature.
Similarly another biodegradation study for read across chemical which was structurally similar to the target chemical (from authoritative database J-CHECK, 2017), was conducted. Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance C.I. Solvent Red 49 (CAS no. 509 -34 -2). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0 and 1% degradation by BOD, TOC removal and HPLC in 28 days. Thus, based on percentage degradation, C.I. Solvent Red 49 was considered to be not readily biodegradable in nature.
In a fifth supporting weight of evidence study from authoritative databases for RA cas (81-88-9) from j-check 2017 was consider as the structurally similarities with target chemical Biodegradation screening study is conducted for 4 weeks. Concentration of inoculum i.e, sludge was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance is determined to be 0, 2 and 7% degradation by BOD, TOC removal and UV-Vis parameter in 28 days. Thus, based on percentage degradation, substance Rhodamine B is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical 3,7-bis(diethylamino)phenoxazin-5-ium acetate (79916-07-7) (from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance peer reviewed journal and authoritative from database J-CHECK, it can be concluded that the test substance 3,7-bis(diethylamino)phenoxazin-5-ium acetate can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3,7-bis(diethylamino) phenoxazin-5-ium acetate (CAS no.79916 -07 -7). If released in to the environment,3.66% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate (CAS no.79916 -07 -7) in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate in sediment is estimated to be 541.66 days (13000 hrs). Based on this half-life value, it indicates that 3,7-bis(diethylamino)phenoxazin-5-ium acetate is persistent in sediment.
Biodegradation in soil:
The half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate (CAS no.79916 -07 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 58.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3,7-bis(diethylamino)phenoxazin-5-ium acetate in soil is estimated to be 120 days ( 2880 hrs). Based on this half-life value of 3,7-bis(diethylamino)phenoxazin-5-ium acetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
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